Evidence map›Paper›PMID 39544149›Full record

Observational studyJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

Alterations of Gut Microbiome Composition and Function Pre- and Post-Adenotonsillectomy in Children with Obstructive Sleep Apnea.

Hai-Hua Chuang, Li-Ang Lee, Li-Pang Chuang, Hsueh-Yu Li, Yu-Shu Huang, Shih-Hsuan Chou, Guo-She Lee, Terry B J Kuo, Cheryl C H Yang, Chung-Guei Huang

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hai-Hua ChuangDepartment of Family Medicine, Taipei Branch and Linkou Main Branch, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Li-Ang LeeSchool of Medicine, College of Life Science and Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Li-Pang ChuangDepartment of Pulmonary and Critical Care Medicine, Linkou Main Branch, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Hsueh-Yu LiDepartment of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Yu-Shu HuangDepartment of Child Psychiatry, Linkou Main Branch, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Shih-Hsuan ChouGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan.
Guo-She LeeDepartment of Otolaryngology, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan.ORCID 0000-0003-4458-9518
Terry B J KuoInstitute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Cheryl C H YangInstitute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chung-Guei HuangDepartment of Laboratory Medicine, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan.ORCID 0000-0002-0598-5684

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceObstructive sleep apnea (OSA) in children is linked with alterations in the gut microbiome. The influence of adenotonsillectomy (AT), a primary intervention for OSA, on gut microbiota dynamics relative to disease severity remains to be elucidated.

objectiveThis study aimed to investigate the impact of OSA severity and AT on the gut microbiome in pediatric patients.

designA prospective observational study.

settingTertiary referral center.

participantsA cohort of 55 pediatric patients treated with AT for OSA.

interventionTotal tonsillectomy and adenoidectomy procedures.

main outcome measuresComprehensive evaluations included in-laboratory polysomnography and 16S rRNA gut microbiome profiling at baseline, and again at 3rd and 12thmonth following surgery.

resultsInitial findings showed uniform α-diversity across different severities of OSA, while β-diversity was significantly elevated in the severe OSA subgroup. Certain gut microbiota taxa ( CONCLUSIONS AND RELEVANCE: This study documents significant changes in the gut microbiome of pediatric patients after AT, including variations in α- and β-diversities, bacterial communities, and inferred metabolic functions. These changes suggest a potential association between the surgical intervention and microbiome alterations, although further studies are necessary to discern the specific contributions of AT amidst possible confounding factors such as antibiotic use.

Indexed as

AdenoidectomyGastrointestinal MicrobiomePolysomnographySleep Apnea, ObstructiveTonsillectomyChildChild, PreschoolFemaleHumansMaleProspective StudiesSeverity of Illness Indexadenotonsillectomyapnea-hypopnea indexfunctional predictiongut microbiomeobstructive sleep apnea

Identifiers

PMID39544149
PMCPMC11565609

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.