Evidence map›Paper›PMID 39544110›Full record

ArticleCancer reports (Hoboken, N.J.)2024

Abemaciclib and Letrozole in Metastatic Male Breast Cancer.

Leon Schönfeld, Christian Möhring, Rouven Strobel, Hanns Leonhard Kaatsch, Stephan Waldeck, Ulrike Wagner

Abstract readCase Reports
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leon SchönfeldDepartment for Internal Medicine, Bundeswehr Central Hospital, Koblenz, Germany.ORCID 0009-0004-0316-4411
Christian MöhringDepartment for Internal Medicine, Bundeswehr Central Hospital, Koblenz, Germany.
Rouven StrobelDepartment for Internal Medicine, Bundeswehr Central Hospital, Koblenz, Germany.
Hanns Leonhard KaatschDepartment for Diagnostic and Interventional Radiology and Neuroradiology, Bundeswehr Central Hospital, Koblenz, Germany.
Stephan WaldeckDepartment for Diagnostic and Interventional Radiology and Neuroradiology, Bundeswehr Central Hospital, Koblenz, Germany.
Ulrike WagnerDepartment for Internal Medicine, Bundeswehr Central Hospital, Koblenz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMale breast cancer is a very rare disease and only accounts for around 1% of all breast cancers. The treatment strategies are based on those used for breast cancer in women. So far, there is a lack of randomized data to support specific treatment modalities in men. To our knowledge, a therapeutic approach with a combination of letrozole and abemaciclib has not yet been described for a male patient with metastatic breast cancer. CASE DESCRIPTION: Here, we report a case of a male patient with advanced metastatic breast cancer treated with a combination of letrozole and abemaciclib. The therapy was well tolerated with no reported side effects. The follow-up CT showed regression of the primary tumor mass and the lymph nodes and soft tissue metastases.

conclusionIn summary, this case report clearly shows the effectiveness of the therapeutic approach and should be discussed for the treatment of future patients.

Indexed as

AminopyridinesAntineoplastic Combined Chemotherapy ProtocolsBenzimidazolesBreast Neoplasms, MaleLetrozoleHumansMaleMiddle AgedTreatment OutcomeabemaciclibAminopyridinesBenzimidazolesLetrozoleabemaciclibCDK4/6 inhibitormale breast cancermetastatic disease

Identifiers

PMID39544110
PMCPMC11564860

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.