Evidence map›Paper›PMID 39544074›Full record

ArticleGut microbes

Prebiotics in food and dietary supplements: a roadmap to EU health claims.

Kieran Tuohy, Elaine E Vaughan, Lucien F Harthoorn, Ellen E Blaak, Philip W J Burnet, Alessandro Busetti, Anirikh Chakrabarti, Nathalie Delzenne, Paul de Vos, Louise Dye and 12 more

Abstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The Gut Microbiome-Endocrine Axis in Obesity: Mechanisms and Therapeutics.Journal of gastroenterology and hepatology · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Kieran TuohySchool of Food Science & Nutrition, University of Leeds, Leeds, UK.
Elaine E VaughanSensus (Royal Cosun), Roosendaal, The Netherlands.
Lucien F HarthoornClasado Ltd, Reading, UK.
Ellen E BlaakDepartment of Human Biology, NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.ORCID 0000-0002-2496-3464
Philip W J BurnetDepartment of Psychiatry, University of Oxford, Oxford, UK.
Alessandro BusettiMetabolon Inc, Morrisville, NC, USA.
Anirikh ChakrabartiCargill R&D Centre Europe, Vilvoorde, Belgium.ORCID 0000-0001-7804-209X
Nathalie DelzenneWoluwe Louvain Drug Research Institute, UCLouvain, Brussels, Belgium.ORCID 0000-0003-2115-6082
Paul de VosPathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands.
Louise DyeInstitute for Sustainable Food, University of Sheffield, Sheffield, UK.
Damien GuillemetNexira, Rouen, France.ORCID 0000-0002-6638-0531
Lesley A HoughtonLeeds Institute of Medical Research, University of Leeds, Leeds, UK.
Alwine F M KardinaalNIZO, Ede, The Netherlands.
Cath MershCath Mersh Communications, Aarhus, Denmark.
Kathy Musa-VelosoIntertek Health Sciences Inc., Mississauga, ON, Canada.
Annegret NielsenAnalyze & Realize GmbH, Berlin, Germany.
Justyna PalasinskaArgenta Barcelona, Barcelona, Spain.
Seppo SalminenCenter for Food and Nutrition Research, Faculty of Medicine, University of Turku, Turku, Finland.
Gemma WaltonFood and Nutritional Sciences, University of Reading, Reading, UK.ORCID 0000-0001-5426-5635
Naomi VenletILSI Europe, Brussels, Belgium.
Charlotte HubermontILSI Europe, Brussels, Belgium.
Philip C CalderSchool of Human Development and Health, Faculty of Medicine, United Kingdom and NIHR Southampton Biomedical, Research Centre, University Hospital NHS Foundation Trust and University of Southampton, Southampton, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous studies have established that prebiotic ingredients in foods and dietary supplements may play a role in supporting human health. Over the three decades that have passed since prebiotics were first defined as a concept, research has revealed a complex universe of prebiotic-induced changes to the human microbiota. There are strong indications of a direct link between these prebiotic-induced changes and specific health benefits. However, at the present time, the EU has not permitted use of the term 'prebiotic' in connection with an approved health claim. This paper is the outcome of a workshop organized on the 25

Indexed as

Dietary SupplementsEuropean UnionGastrointestinal MicrobiomePrebioticsCongresses as TopicHumansPrebioticsbiomarkercognitivedigestiveEFSAEUhealth claimimmunemetabolicmetabolitemicrobiotaPrebiotic

Identifiers

PMID39544074
PMCPMC11572068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.