Evidence map›Paper›PMID 39543986›Full record

ArticleGlia2025

Astrocytic NHERF-1 Increases Seizure Susceptibility by Inhibiting Surface Expression of TREK-1.

Yeonju Bae, Soomin Lee, Ajung Kim, Shinae Lee, Seong-Seop Kim, Sunyoung Park, Junyeol Noh, Kanghyun Ryoo, Gwan-Su Yi, Jae-Yong Park and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. TREK-1 and epilepsy: regulating the balance of KBehavioral and brain functions : BBF · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yeonju BaeBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Soomin LeeBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Ajung KimBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Shinae LeeBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Seong-Seop KimSchool of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul, Republic of Korea.
Sunyoung ParkSchool of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul, Republic of Korea.
Junyeol NohSchool of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul, Republic of Korea.
Kanghyun RyooSchool of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul, Republic of Korea.
Gwan-Su YiDepartment of bio and Brain Engineering, College of Engineering, KAIST, Daejeon, Republic of Korea.
Jae-Yong ParkSchool of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul, Republic of Korea.ORCID 0000-0001-7698-7890
Eun Mi HwangBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.ORCID 0000-0002-3130-8572

Funding

Korea Institute of Science and Technology 2E32901National Research Foundation of Korea 2020R1A2C2010650National Research Foundation of Korea 2022R1A2C1093143
6 · The paper itself

Abstract

Mature hippocampal astrocytes exhibit a linear current-to-voltage (I-V) K

Indexed as

AstrocytesPhosphoproteinsPotassium Channels, Tandem Pore DomainSeizuresSodium-Hydrogen ExchangersAnimalsCells, CulturedHippocampusHumansKainic AcidMaleMiceRatsRats, Sprague-DawleyKainic AcidPhosphoproteinspotassium channel protein TREK-1Potassium Channels, Tandem Pore Domainsodium-hydrogen exchanger regulatory factorSodium-Hydrogen Exchangersastrocytic passive conductancekainic acid‐induced seizuresNHERF‐1TREK‐1

Identifiers

PMID39543986
PMCPMC11845839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.