ArticleJournal of orthopaedic surgery and research2024
lncRNA CASC11 regulates the progress of delayed fracture healing via sponging miR-150-3p.
Article in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Isopsoralen Promotes Mandibular Fracture Healing by Regulating Autophagy.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- miR-211-5p/FOXO3 axis accelerates osteogenic differentiation and fracture healing by mediating Wnt/β-catenin pathway.Journal of orthopaedic surgery and research · 2026Article
- Comparative effects of thiocolchicoside and etodolac on fracture healing in a rat femur model.Journal of orthopaedic surgery and research · 2026Article
- let-7c-5p promotes fracture healing by downregulating CDK8.Journal of orthopaedic surgery and research · 2026Article
- Upregulation of lncRNA SSTR5-AS1 promotes osteoblast differentiation and reduces apoptosis.Journal of orthopaedic surgery and research · 2025Article
- Serum DLX6-AS1 and miR-141-3p as early diagnostic biomarkers and regulators of delayed fracture healing (DFH).Journal of orthopaedic surgery and research · 2025Article
- The mechanism of lncRNA LINC01446 in delayed fracture healing and its clinical significance.Journal of orthopaedic surgery and research · 2025Article
- LncRNA MIR22HG promotes fracture healing through down-regulation of miR-10a-5p.Journal of orthopaedic surgery and research · 2025Article
- Huo Xue Tong Luo capsule epigenetically activates β-catenin, promotes Prx1-lineage cells proliferation and endochondral bone formation during fracture healing.Journal of orthopaedic surgery and research · 2025Article
- Platelet-rich plasma enhanced therapy for aseptic atrophic tibial diaphyseal nonunion: a single-center retrospective controlled study of 90 cases.Journal of orthopaedic surgery and research · 2025Article
- LINC00341 promotes fracture healing through downregulation of miR-133a-3p.Journal of orthopaedic surgery and research · 2025Article
- Functional mechanism and clinical implications of miR-455-5p in delayed fracture healing.Journal of orthopaedic surgery and research · 2025Article
- miR-34c-5p targets Notch2 to promote fracture healing.Journal of orthopaedic surgery and research · 2025Article
- MiR-376a-3p inhibits bone repair by regulating osteoblastic differentiation.Journal of orthopaedic surgery and research · 2025Article
- Exenatide, a glucagon-like peptide-1 receptor agonist, may negatively impact bone healing in rats: histopathological, biochemical, and in silico findings.Journal of orthopaedic surgery and research · 2025Article
- MiR-148a-3p regulates the fracture healing process by targeting MAFB.Journal of orthopaedic surgery and research · 2025Article
- LncRNA LINC01123-mediated impaired fracture healing through miR-134-5p/XIAP axis.Journal of orthopaedic surgery and research · 2025Article
- The diagnostic and therapeutic potential of miR-3149 in osteoporotic fractures through SMAD4.Journal of orthopaedic surgery and research · 2025Article
- Functional mechanism and clinical implications of lncRNA NEAT1 in traumatic fractures and their correlation with delayed healing.Journal of orthopaedic surgery and research · 2025Article
- LncRNA GABARAPL2 promotes non‑union long bone fractures by suppressing bone mesenchymal stromal cell osteogenesis.Journal of orthopaedic surgery and research · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong non-coding RNA (lncRNA) plays a pivotal role in bone regeneration by interaction with microRNAs (miRNAs) and constructing a lncRNA-miRNA regulatory network.
objectivesThis research aimed to elucidate the role of lncRNA CASC11 in the delayed healing process of tibial fractures and to explore its potential regulatory mechanisms. MATERIALS AND
methodsThe expression levels of CASC11 and miR-150-3p in serum samples were detected and the predictive capability of CASC11 regarding delayed healing in fracture patients. Furthermore, the study confirmed the accuracy of the binding sites between CASC11 and miR-150-3p. Subsequently, overexpression/interference plasmids of CASC11, along with overexpression plasmids co-transfected with both CASC11 and miR-150-3p, were systematically introduced into MC3T3-E1 cells to investigate their effects on the expression of osteogenic marker genes, as well as their influence on cellular proliferation and apoptosis.
resultsThe expression levels of CASC11 were significantly elevated, while miR-150-3p levels were markedly decreased in individuals exhibiting delayed fracture healing (P < 0.001). CASC11 was observed to suppress the expression of osteogenic marker genes, inhibit the proliferation of MC3T3-E1 cells, and promote cell apoptosis (P < 0.05). Furthermore, the overexpression of miR-150-3p effectively countered the inhibitory impact of CASC11 on osteogenic differentiation and the promoting effect on cell apoptosis (P < 0.05).
conclusionThe sponging effect of CASC11 on miR-150-3p led to delayed fracture healing. CASC11 emerges as a potential target for treating delayed fracture healing.
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