Evidence map›Paper›PMID 39543563›Full record

Observational studyBMC pregnancy and childbirth2024

Administration patterns of magnesium sulphate for women with preeclampsia and immediate newborn outcomes in Kawempe National Referral Hospital-Uganda: a cohort study.

Mariam Birungi, Jane Nakibuuka, Mark Kaddumukasa, Josephine Najjuma, Christopher J Burant, Shirley Moore, Carol Blixen, Elly T Katabira, Martha Sajatovic, Scovia Nalugo Mbalinda

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mariam BirungiDepartment of Nursing, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda. marbir64@gmail.com.
Jane NakibuukaDepartment of Medicine, Mulago Hospital, P.O. Box 7051, Kampala, Uganda.
Mark KaddumukasaDepartment of Medicine, School of Medicine, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
Josephine NajjumaDepartment of Nursing, Mbarara University of Science and Technology, PO Box 1410, Mbarara, Uganda.
Christopher J BurantCase Western Reserve University Us, Louis Stokes VA Medical Center US, Geriatric Research Education, and Clinical Center, 10701 East Boulevard, Cleveland, OH, 44106, USA.
Shirley MooreFrances Payne Bolton School of Nursing, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Carol BlixenNeurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center & Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
Elly T KatabiraDepartment of Medicine, School of Medicine, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
Martha SajatovicNeurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center & Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
Scovia Nalugo MbalindaDepartment of Nursing, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.

Funding

A Targeted Self-Management Intervention for Reducing Stroke Risk Factors in High Risk UgandansR01NS118544 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KATABIRA, ELLY T, SAJATOVIC, MARTHA X · 2020 to 2025
$3.0M
NINDS NIH HHS R01 NS118544
6 · The paper itself

Abstract

backgroundPreeclampsia is the second leading cause of maternal death in Uganda. WHO recommends using magnesium sulphate (MgSO4) to prevent and treat preeclampsia with severe features (PEC) and eclampsia. MgSO4 is used to prevent eclampsia and treat women who experience an eclamptic convulsion to avoid severe maternal/infant illnesses and death. We set out to assess MgSO4 administration patterns in women with PEC or eclampsia and the immediate newborn outcomes of neonates.

methodsThis was an analytical observational cohort study at Kawempe National Referral Hospital in Uganda. Two hundred ten pregnant mothers with PEC or eclampsia were recruited in the study after receiving the loading dose of MgSO4 and then followed through labour and delivery to observe MgSO4 administration patterns and immediate newborn outcomes using Apgar and Thompson scores. SPSS version 23 was used to analyse data, and both bivariate and multivariate logistic regressions were used to determine factors associated with the low Apgar score at five minutes.

resultsOverall, majority of the patients received more than one dose with 33.3% received a sixth dose of MgSO4. The majority, 84.8%, of the mothers delivered live babies, 31.0% babies had complications, and were admitted to the neonatal intensive care unit (NICU). NICU admissions were mostly due to respiratory distress21.4%, preterm delivery21.0%, and 5.5% died within seven days. Majority 93.3% of the newborns had an Apgar score of seven and above at five minutes, of the newborns who were Thompson scored, 70.4% scored between 1 to 10 which is mild HIE. Initiation of MgSO4 treatment within one hour from prescription (AOR = 0.49, CI: 0.01-1.94), 4-hourly timing of the first maintenance dose (AOR = 0.22, CI: 0.06-0.79) and having complete doses of MgSO4 treatment (AOR = 0.89, CI: 0.03-3.05) decreased the likelihood of having low Apgar scores at five minutes.

conclusionsTimely administration of the first maintenance dose of MgSO4 decreases the likelihood of low Apgar score at 5 min and NICU admission in newborns, and most NICU admissions were due to respiratory distress and preterm delivery.

Indexed as

Apgar ScoreMagnesium SulfatePre-EclampsiaAdultAnticonvulsantsCohort StudiesEclampsiaFemaleHumansInfant, NewbornIntensive Care Units, NeonatalPregnancyPregnancy OutcomeUgandaYoung AdultAnticonvulsantsMagnesium SulfateApgar scoreIntrapartumMagnesium sulphateNewborn outcomesPreeclampsiaUganda

Identifiers

PMID39543563
PMCPMC11566436

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.