Evidence map›Paper›PMID 39543437›Full record

ArticleFEBS letters2024

Crystal structure of β-d-galactofuranosidase from Streptomyces sp. JHA19 in complex with an inhibitor provides insights into substrate specificity.

Noriki Fujio, Chihaya Yamada, Toma Kashima, Emiko Matsunaga, Robert J Nash, Kaoru Takegawa, Shinya Fushinobu

Abstract read
In one paragraph

Article in FEBS letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Noriki FujioDepartment of Biotechnology, The University of Tokyo, Japan.
Chihaya YamadaSchool of Agriculture, Meiji University, Kawasaki, Japan.
Toma KashimaDepartment of Biotechnology, The University of Tokyo, Japan.
Emiko MatsunagaDepartment of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Robert J NashInstitute of Biological, Environmental and Rural Sciences/Phytoquest Limited, Aberystwyth, UK.
Kaoru TakegawaDepartment of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.ORCID https://orcid.org/0000-0003-3477-7216
Shinya FushinobuDepartment of Biotechnology, The University of Tokyo, Japan.ORCID https://orcid.org/0000-0003-1346-6435

Funding

AMED JP22ama121001JSPS-KAKENHI 17H03966JSPS-KAKENHI 19H00929JSPS-KAKENHI 21K15025JSPS-KAKENHI 21K19090JSPS-KAKENHI 23H00322JSPS-KAKENHI 23K23511
6 · The paper itself

Abstract

d-Galactofuranose (Galf) is widely distributed in glycoconjugates of pathogenic microbes. β-d-Galactofuranosidase (Galf-ase) from Streptomyces sp. JHA19 (ORF1110) belongs to glycoside hydrolase (GH) family 2 and is the first identified Galf-specific degradation enzyme. Here, the crystal structure of ORF1110 in complex with a mechanism-based potent inhibitor, d-iminogalactitol (K

Indexed as

Catalytic DomainEnzyme InhibitorsGlycoside HydrolasesStreptomycesAmino Acid SequenceBacterial ProteinsCrystallography, X-RayModels, MolecularProtein BindingSubstrate SpecificityBacterial ProteinsEnzyme Inhibitorsexo-beta-D-galactofuranosidaseGlycoside Hydrolasesglycoside hydrolase family 2mechanism‐based inhibitorα‐l‐arabinofuranoseβ‐galactosidaseβ‐glucuronidase

Identifiers

PMID39543437
PMCPMC11627007

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.