ArticleMolecular psychiatry2025
The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder.
Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A scoping review of the relationship between autistic traits and eating disorders: exploring the secondary impact of eating disorders and co-occurring psychiatric diagnoses.Frontiers in psychiatry · 2026Pooled it
- Considering Autism in Binge-Type Eating Disorders: Broadening Beyond an Anorexia Nervosa-Focused Model.Current psychiatry reports · 2026Review
- Pica, avoidant restrictive food intake disorder and rumination disorder in children and adolescents with autism spectrum disorder: A systematic review.Journal of eating disorders · 2026Review
- A unified theory of restrictive and addictive eating: a life course model integrating generational transmission, neurodevelopmental risk, and ultra-processed food use disorder-a theoretical review.Journal of eating disorders · 2026Review
- Article
- Maternal body mass index in early pregnancy and autism in offspring: a population-based cohort study in Sweden and Denmark.BMC medicine · 2025Article
- Social camouflaging of autistic traits is associated with more severe symptoms among subjects with feeding and eating disorders.Eating and weight disorders : EWD · 2025Article
- Neurocognitive Profiles in Parents of Autistic Children and Parents of Children with Anorexia Nervosa.Journal of autism and developmental disorders · 2025Article
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18 authors.
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Abstract
Eating disorders (EDs) commonly co-occur with other psychiatric and neurodevelopmental disorders including attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD); however, the pattern of family history and genetic overlap among them requires clarification. This study investigated the diagnostic, familial, and genetic associations of EDs with ADHD and ASD. The nationwide population-based cohort study included all individuals born in Denmark, 1981-2008, linked to their siblings and cousins. Cox regression was used to estimate associations between EDs and ADHD or ASD, and mediation analysis was used to assess the effects of intermediate mood or anxiety disorders. Polygenic scores (PGSs) were used to investigate the genetic association between anorexia nervosa (AN) and ADHD or ASD. Significantly increased risk for any ED was observed following an ADHD or ASD diagnosis. Mediation analysis suggested that intermediate mood or anxiety disorders could account for 44%-100% of the association between ADHD or ASD and ED. Individuals with a full sibling or maternal half sibling with ASD had increased risk of AN compared to those with siblings without ASD. A positive association was found between ASD-PGS and AN risk whereas a negative association was found between AN-PGS and ADHD. In this study, positive phenotypic associations between EDs and ADHD or ASD, mediation by mood or anxiety disorder, and genetic associations between ASD-PGS and AN and between AN-PGS and ADHD were observed. These findings could guide future research in the development of new treatments that can mitigate the development of EDs among individuals with ADHD or ASD.
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