Evidence map›Paper›PMID 39543363›Full record

ArticleNature cancer2024

Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity.

Jingyi Yang, Xiaole Song, Huankang Zhang, Quan Liu, Ruoyan Wei, Luo Guo, Cuncun Yuan, Fu Chen, Kai Xue, Yuting Lai and 29 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Jingyi Yang *ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.ORCID http://orcid.org/0000-0002-9781-7054
Xiaole Song *ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Huankang ZhangENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Quan LiuENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Ruoyan WeiDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Luo GuoENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Cuncun YuanDepartment of Pathology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Fu ChenDepartment of Radiation Oncology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Kai XueENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Yuting LaiENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Li WangENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Junfeng ShiENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Chengle ZhouENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Juan WangState Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Pharmaceutical Industry Research Institute, Shanghai, PR China.
Yingxuan YuState Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Pharmaceutical Industry Research Institute, Shanghai, PR China.
Qibing MeiState Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Pharmaceutical Industry Research Institute, Shanghai, PR China.
Li HuDepartment of Experimental Center, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Huan WangENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Chen ZhangENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Qianqian ZhangENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Houyong LiENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Ye GuDepartment of Neurosurgery and Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Weidong ZhaoDepartment of Neurosurgery and Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Huapeng YuENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Jingjing WangENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Zhuofu LiuENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Han LiENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Shixing ZhengENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Juan LiuENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Lu YangENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Wanpeng LiENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Rui XuENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Jiani ChenENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Yumin ZhouENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Xiankui ChengDepartment of Pathology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, PR China.
Yiqun YuENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Dehui WangENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.
Xicai SunENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China.ORCID http://orcid.org/0000-0003-1423-0942
Hongmeng YuENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China. hongmengyush@fudan.edu.cn.ORCID http://orcid.org/0000-0002-2578-9103

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81970856National Natural Science Foundation of China (National Science Foundation of China) 82303862National Natural Science Foundation of China (National Science Foundation of China) 82371123Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 20Y11902000Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 21ZR1411700Shanghai Shen Kang Hospital Development Center SHDC22021214
6 · The paper itself

Abstract

Olfactory neuroblastoma (ONB) is a rare malignancy known to originate from the olfactory epithelium. The complex tumor ecosystem of this pathology remains unclear. Here, we explored the cellular components within ten ONB tumors and one olfactory mucosa sample based on single-cell RNA profiles. We showed the intra-tumoral heterogeneity by identifying five unique expression programs among malignant epithelial cells. A distinct three-classification system (neural, basal, mesenchymal) for ONB was established according to the distinguished gene expression patterns. Biomarkers for categorizing bulk tumors into uncharacterized subtypes were elucidated. Different responses towards certain chemotherapy regimens could be cautiously inferred according to the molecular features representing the three tumor types, thus helping with precision chemotherapy. We also analyzed subclusters of the tumor microenvironment (TME) and the interactions among different cell types within the TME. The relative abundance of immunosuppressive tumor-associated macrophages suggests potential benefits of immunotherapies targeting macrophages.

Indexed as

Esthesioneuroblastoma, OlfactoryNose NeoplasmsSingle-Cell AnalysisTranscriptomeTumor MicroenvironmentBiomarkers, TumorFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenetic HeterogeneityHumansMaleMiddle AgedOlfactory MucosaTumor-Associated MacrophagesBiomarkers, Tumor

Identifiers

PMID39543363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.