ArticleNature communications2024
A hierarchical active inference model of spatial alternation tasks and the hippocampal-prefrontal circuit.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Active inference with reusable state-dependent value profiles.Biological cybernetics · 2026Article
- Inferential planning in the frontal cortex.Cell reports · 2026Article
- Active inference as a model of collision avoidance behavior in human drivers.Nature communications · 2026Article
- Fleeing is believing: adaptive behavior under social threat as an inference process.Frontiers in neural circuits · 2026Article
- Shared worlds, shared minds : Strategies to develop physically and socially embedded AI.EMBO reports · 2025Article
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Authors and funding
4 authors.
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Abstract
Cognitive problem-solving benefits from cognitive maps aiding navigation and planning. Physical space navigation involves hippocampal (HC) allocentric codes, while abstract task space engages medial prefrontal cortex (mPFC) task-specific codes. Previous studies show that challenging tasks, like spatial alternation, require integrating these two types of maps. The disruption of the HC-mPFC circuit impairs performance. We propose a hierarchical active inference model clarifying how this circuit solves spatial interaction tasks by bridging physical and task-space maps. Simulations demonstrate that the model's dual layers develop effective cognitive maps for physical and task space. The model solves spatial alternation tasks through reciprocal interactions between the two layers. Disrupting its communication impairs decision-making, which is consistent with empirical evidence. Additionally, the model adapts to switching between multiple alternation rules, providing a mechanistic explanation of how the HC-mPFC circuit supports spatial alternation tasks and the effects of disruption.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.