ArticleMethods in molecular biology (Clifton, N.J.)2025
Building Up Functional Coiled-Coil-Based Supramolecular Assemblies for Biomedical and Biotechnological Applications.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
The self-assembling nature of coiled-coils has brought this common structural motif into the spotlight of protein design since it offers a customizable framework for engineering innovative protein nanoparticles with tailored functionalities. We recently harnessed the self-assembling capabilities of ZapB, a bacterial coiled-coil protein, to build up fluorescent protein nanoparticles possessing remarkable affinity for antibodies. Here, we describe a complete workflow detailing the design, production, and characterization of such coiled-coil-based protein nanostructures. Additionally, we detail their functionalization with specific antibodies and illustrate their utility in stimulating the activation and proliferation of human T cells, underscoring the potential of these protein-only nanoparticles in immunotherapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.