ReviewMethods in molecular biology (Clifton, N.J.)2025
Recent Advances in Computational Prediction of Secondary and Supersecondary Structures from Protein Sequences.
Review in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- ToxDL 2.0: Protein toxicity prediction using a pretrained language model and graph neural networks.Computational and structural biotechnology journal · 2025Article
- Comprehensive assessment of AlphaFold's predictions of secondary structure and solvent accessibility at the amino acid-level in eukaryotic, bacterial and archaeal proteins.Computational and structural biotechnology journal · 2025Article
- Twenty years of advances in prediction of nucleic acid-binding residues in protein sequences.Briefings in bioinformatics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The secondary structures (SSs) and supersecondary structures (SSSs) underlie the three-dimensional structure of proteins. Prediction of the SSs and SSSs from protein sequences enjoys high levels of use and finds numerous applications in the development of a broad range of other bioinformatics tools. Numerous sequence-based predictors of SS and SSS were developed and published in recent years. We survey and analyze 45 SS predictors that were released since 2018, focusing on their inputs, predictive models, scope of their prediction, and availability. We also review 32 sequence-based SSS predictors, which primarily focus on predicting coiled coils and beta-hairpins and which include five methods that were published since 2018. Substantial majority of these predictive tools rely on machine learning models, including a variety of deep neural network architectures. They also frequently use evolutionary sequence profiles. We discuss details of several modern SS and SSS predictors that are currently available to the users and which were published in higher impact venues.
Indexed as
Identifiers
39543027What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.