Evidence map›Paper›PMID 39542958›Full record

ArticleInternational ophthalmology2024

Lacrimal gland enlargement in thyroid eye disease.

Khizar Rana, Carmelo Caltabiano, Mark Beecher, Sandy Patel, James Slattery, Weng Onn Chan, Garry Davis, Dinesh Selva

Abstract read
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In one paragraph

Article in International ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Medication-associated thyroid eye disease: a review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Imaging features of lacrimal gland disease.Frontiers in ophthalmology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khizar RanaDepartment of Ophthalmology and Visual Sciences, University of Adelaide, North Terrace, SA, 5000, Australia. khizar.rana@adelaide.edu.au.
Carmelo CaltabianoDepartment of Ophthalmology and Visual Sciences, University of Adelaide, North Terrace, SA, 5000, Australia.
Mark BeecherDepartment of Ophthalmology and Visual Sciences, University of Adelaide, North Terrace, SA, 5000, Australia.
Sandy PatelDepartment of Medical Imaging, Royal Adelaide Hospital, Port Road, Adelaide, SA, 5000, Australia.
James SlatteryDepartment of Ophthalmology and Visual Sciences, University of Adelaide, North Terrace, SA, 5000, Australia.
Weng Onn ChanDepartment of Ophthalmology and Visual Sciences, University of Adelaide, North Terrace, SA, 5000, Australia.
Garry DavisDepartment of Ophthalmology and Visual Sciences, University of Adelaide, North Terrace, SA, 5000, Australia.
Dinesh SelvaDepartment of Ophthalmology and Visual Sciences, University of Adelaide, North Terrace, SA, 5000, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to investigate lacrimal gland (LG) enlargement in thyroid eye disease (TED) patients on magnetic resonance imaging (MRI).

methodsA retrospective review was conducted on TED patients who had undergone fat-suppressed contrast-enhanced T1-weighted MRI of the orbits. The lacrimal gland was segmented on OsiriX in consecutive axial and coronal slices to determine its volume. Enlargement was defined as a volume greater than 1100mm

resultsThe study population consisted of 88 orbits from forty-four patients with a mean age of 53 ± 15 years, with 29 (65%) being female. Twelve patients (27%) had LG enlargement, with eight (18%) having bilateral enlargement and four (9%) having asymmetric enlargement. There was no significant difference in age (p = 0.17) or sex (p = 0.44) between the LG enlarged and non-enlarged groups. There was also no significant difference in the clinical activity (p = 0.46) or prevalence of dysthyroid optic neuropathy (p = 0.63) between the LG enlarged orbits and non-LG enlarged orbits.

conclusionLacrimal gland enlargement may be observed in approximately thirty percent of TED patients, with asymmetric enlargement in approximately ten percent of cases.

Indexed as

Graves OphthalmopathyLacrimal ApparatusMagnetic Resonance ImagingAdultAgedFemaleHumansHypertrophyMaleMiddle AgedRetrospective StudiesGravesLacrimal glandMagnetic resonance imagingThyroid eye disease

Identifiers

PMID39542958

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.