Evidence map›Paper›PMID 39542948›Full record

ArticleAbdominal radiology (New York)2025

Dynamic changes of radiological and radiomics patterns based on MRI in viable hepatocellular carcinoma after transarterial chemoembolization.

Weilang Wang, Shuhang Zhang, Binyan Zhong, Wu Cai, Lei Gao, Binrong Li, Dandan Yao, Yuan Zhao, Ziying Sun, Shuwei Zhou and 4 more

Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03113955 (A Single-arm Trial of Transcatheter Arterial Chemoembolization With Tandem Microspheres in the Treatment of Localized Hepatocellular Carcinoma), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03113955 nacompletednot on this map

A Single-arm Trial of Transcatheter Arterial Chemoembolization With Tandem Microspheres in the Treatment of Localized Hepatocellular Carcinoma

TypeinterventionalSponsorVarian Medical SystemsRan2017 to 2020Enrolled109ConditionsLocalized Hepatocellular CarcinomaArmsTandem Microsphere loaded with Epirubicin
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Weilang WangZhongda Hospital Southeast University, Nanjing, China.
Shuhang ZhangZhongda Hospital Southeast University, Nanjing, China.
Binyan ZhongFirst Affiliated Hospital of Soochow University, Suzhou, China.
Wu CaiSecond Affiliated Hospital of Soochow University, Suzhou, China.
Lei GaoNanjing University of Information Science and Technology, Nanjing, China.
Binrong LiZhongda Hospital Southeast University, Nanjing, China.
Dandan YaoZhongda Hospital Southeast University, Nanjing, China.
Yuan ZhaoZhongda Hospital Southeast University, Nanjing, China.
Ziying SunZhongda Hospital Southeast University, Nanjing, China.
Shuwei ZhouZhongda Hospital Southeast University, Nanjing, China.
Teng ZhangNanjing University of Information Science and Technology, Nanjing, China.
Xunjun ChenThe Peoples Hospital of Xuyi County, Huaian, China.
Shenghong JuZhongda Hospital Southeast University, Nanjing, China.
Yuan-Cheng WangZhongda Hospital Southeast University, Nanjing, China. yuancheng_wang@seu.edu.cn.

Funding

National Natural Science Foundation of China 82271978National Natural Science Foundation of China 92359304Zhongda Hospital Affiliated to Southeast University, Jiangsu Province High-Level Hospital Pairing Assistance Construction Funds No. zdyyxy09
6 · The paper itself

Abstract

objectivesThis study aims to analyze the magnetic resonance imaging (MRI) change patterns of viable hepatocellular carcinomas (HCCs) following the initial transarterial chemoembolization (TACE).

methodsA retrospective analysis of HCC patients' initial TACE from February 2015 to October 2022 across three centers and a clinical trial (NCT03113955) was conducted. The viability of residual HCCs at one and six months after TACE was evaluated using the LI-RADS Treatment Response Algorithm (LR-TRA) v2024. The radiological and radiomics features of post-TACE viable tumors between baseline and one-month, and between one- and six- months were compared using Wilcoxon signed-rank test and McNemar's test.

resultsA total of 160 viable tumors were included in the study. Viable tumors at one month after TACE exhibited higher T1WI intensity (P =.024), lower T2WI intensity (P =.005), fewer washout features (P <.001), smaller size (P <.001), and higher ADC values (P <.001) compared to baseline HCC imaging.A significant reduction in DWI intensity (P =.002) and ADC values (P <.001) were observed in viable tumors at one month compared to those at six months. There were 82 (45.1%) radiomics features that changed significantly between the baseline and one-month. Only three radiomics features showed statistically significant difference of viable tumors between one- and six-month.

conclusionsCompared to the baseline, viable HCCs after TACE demonstrated significant changes of imaging characteristics in a series of radiological and radiomics features at one- and six-month follow-ups. CLINICAL RELEVANCE STATEMENT: Clinically diagnosing of viable HCCs using radiological methods is challenging. A comprehensive analysis of these imaging characteristics can facilitate the accurate identification of viable tumors.

Indexed as

Carcinoma, HepatocellularChemoembolization, TherapeuticLiver NeoplasmsMagnetic Resonance ImagingAgedFemaleHumansLiverMaleMiddle AgedRadiomicsRetrospective StudiesTreatment OutcomeHepatocellular carcinomaMagnetic resonance imagingRadiomicsTransarterial chemoembolizationViable tumors

Identifiers

PMID39542948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.