Evidence map›Paper›PMID 39542942›Full record

ReviewDiscover nano2024

Nanorobots mediated drug delivery for brain cancer active targeting and controllable therapeutics.

Mengze Xu, Zhaoquan Qin, Zhichao Chen, Shichao Wang, Liang Peng, Xiaoli Li, Zhen Yuan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mengze Xu *Center for Cognition and Neuroergonomics, Center for Advanced Materials Research, Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, 519087, People's Republic of China. mengzexu@bnu.edu.cn.
Zhaoquan Qin *School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, People's Republic of China.
Zhichao Chen *College of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou, 362000, Fujian, People's Republic of China.
Shichao WangCenter for Cognition and Neuroergonomics, Center for Advanced Materials Research, Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, 519087, People's Republic of China. scwang@bnu.edu.cn.
Liang PengSchool of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, People's Republic of China. pengliang8036@163.com.
Xiaoli LiCenter for Cognition and Neuroergonomics, Center for Advanced Materials Research, Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, 519087, People's Republic of China. xiaoli@bnu.edu.cn.
Zhen YuanCentre for Cognitive and Brain Sciences, Faculty of Health Sciences, University of Macau, Macau, SAR 999078, People's Republic of China. zhenyuan@um.edu.mo.

Funding

Fundo para o Desenvolvimento das Ciências e da Tecnologia FDCT 0020/2019/AMJ and FDCT 0011/2018/A1Hospital-level scientific research fund of Yunfu People's Hospital A20231006National Major Projects in Brain Science and Brain-Like Research 2021ZD0204300Start-Up Fund for Introduced Talents and Scientific Research at Beijing Normal University 28709-312200502501Universidade de Macau MYRG 2020-00067-FHS, MYRG2019-00082-FHS and MYRG2018-00081-FHS)
6 · The paper itself

Abstract

Brain cancer pose significant life-threats by destructively invading normal brain tissues, causing dysneuria, disability and death, and its therapeutics is limited by underdosage and toxicity lying in conventional drug delivery that relied on passive delivery. The application of nanorobots-based drug delivery systems is an emerging field that holds great potential for brain cancer active targeting and controllable treatment. The ability of nanorobots to encapsulate, transport, and supply therapies directly to the lesion site through blood-brain barriers makes it possible to deliver drugs to hard-to-reach areas. In order to improve the efficiency of drug delivery and problems such as precision and sustained release, nanorobots are effectively realized by converting other forms of energy into propulsion and motion, which are considered as high-efficiency methods for drug delivery. In this article, we described recent advances in the treatment of brain cancer with nanorobots mainly from three aspects: firstly, the development history and characteristics of nanorobots are reviewed; secondly, recent research progress of nanorobots in brain cancer is comprehensively investigated, like the driving mode and mechanism of nanorobots are described; thirdly, the potential translation of nanorobotics for brain diseases is discussed and the challenges and opportunities for future research are outlined.

Indexed as

Active targetingBrain cancerControllable therapeuticsPrecise oncologyTargeted drug delivery nanorobots

Identifiers

PMID39542942
PMCPMC11564721

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.