Evidence map›Paper›PMID 39542651›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Decreased temporal variabilities of functional connectivities in insula and lingual gyrus are associated with better early treatment response in patients with panic disorder.

Linlin You, Wenhao Jiang, Xiaotong Zhang, Yueying Li, Jiayin Wei, Yue Zhou, Suzhen Chen, Na Lu, Yingying Yue, Youyong Kong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Linlin You *From the Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China (You, Jiang, Zhou, Chen, Lu, Yue, Yuan); the Nanjing Medical University, Nanjing, China (You, Yuan); Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, China (Zhang, Li, Wei, Kong).
Wenhao Jiang *From the Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China (You, Jiang, Zhou, Chen, Lu, Yue, Yuan); the Nanjing Medical University, Nanjing, China (You, Yuan); Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, China (Zhang, Li, Wei, Kong).
Xiaotong ZhangFrom the Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China (You, Jiang, Zhou, Chen, Lu, Yue, Yuan); the Nanjing Medical University, Nanjing, China (You, Yuan); Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, China (Zhang, Li, Wei, Kong).
Yueying LiFrom the Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China (You, Jiang, Zhou, Chen, Lu, Yue, Yuan); the Nanjing Medical University, Nanjing, China (You, Yuan); Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, China (Zhang, Li, Wei, Kong).
Jiayin WeiFrom the Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China (You, Jiang, Zhou, Chen, Lu, Yue, Yuan); the Nanjing Medical University, Nanjing, China (You, Yuan); Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, China (Zhang, Li, Wei, Kong).
Yue ZhouFrom the Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China (You, Jiang, Zhou, Chen, Lu, Yue, Yuan); the Nanjing Medical University, Nanjing, China (You, Yuan); Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, China (Zhang, Li, Wei, Kong).
Suzhen ChenFrom the Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China (You, Jiang, Zhou, Chen, Lu, Yue, Yuan); the Nanjing Medical University, Nanjing, China (You, Yuan); Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, China (Zhang, Li, Wei, Kong).
Na LuFrom the Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China (You, Jiang, Zhou, Chen, Lu, Yue, Yuan); the Nanjing Medical University, Nanjing, China (You, Yuan); Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, China (Zhang, Li, Wei, Kong).
Yingying YueFrom the Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China (You, Jiang, Zhou, Chen, Lu, Yue, Yuan); the Nanjing Medical University, Nanjing, China (You, Yuan); Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, China (Zhang, Li, Wei, Kong).
Youyong KongFrom the Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China (You, Jiang, Zhou, Chen, Lu, Yue, Yuan); the Nanjing Medical University, Nanjing, China (You, Yuan); Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, China (Zhang, Li, Wei, Kong). kongyouyong@seu.edu.cn yygylh2000@sina.com.
Yonggui YuanFrom the Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China (You, Jiang, Zhou, Chen, Lu, Yue, Yuan); the Nanjing Medical University, Nanjing, China (You, Yuan); Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, China (Zhang, Li, Wei, Kong). kongyouyong@seu.edu.cn yygylh2000@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPanic disorder is a common disabling condition with limited biomarkers. We aimed to explore the diagnostic and treatment response prediction value of functional temporal variability in people with panic disorder.

methodsPatients with panic disorder and healthy controls received resting-state functional magnetic resonance imaging scans and assessments. After 2 weeks of treatment, the patients with panic disorder were divided into remitted (RPD;

resultsOur sample included 82 patients with panic disorder (39 RPD, 43 NRPD) and 105 controls. The panic disorder group showed decreased temporal variability in the left posterior cingulate gyrus (PCG), right lingual gyrus, right fusiform gyrus, and right thalamus (all LIMITATIONS: Functional brain images were collected only at baseline and may have been affected by medication use. Also, the follow-up period was only 2 weeks; sustained clinical remission may require longer follow-up.

conclusionCombining lingual gyrus, PCG, and thalamus temporal variability alterations helped distinguish patients with panic disorder from healthy controls. The temporal variability in the insula and lingual gyrus are potential biomarkers for the treatment of panic disorder.

Indexed as

Magnetic Resonance ImagingPanic DisorderAdultCerebral CortexFemaleHumansInsular CortexMaleThalamusTreatment Outcome

Identifiers

PMID39542651
PMCPMC11573430

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.