Evidence map›Paper›PMID 39542647›Full record

ArticleGenome research2025

ISWI1 complex proteins facilitate developmental genome editing in

Aditi Singh, Lilia Häußermann, Christiane Emmerich, Emily Nischwitz, Brandon K B Seah, Falk Butter, Mariusz Nowacki, Estienne C Swart

Abstract read
In one paragraph

Article in Genome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aditi Singh *Max Planck Institute for Biology, 72076 Tübingen, Germany; estienne.swart@tuebingen.mpg.de aditi.singh@tuebingen.mpg.de.ORCID 0000-0001-7840-9058
Lilia Häußermann *Max Planck Institute for Biology, 72076 Tübingen, Germany.
Christiane EmmerichMax Planck Institute for Biology, 72076 Tübingen, Germany.
Emily NischwitzInstitute of Molecular Biology, 55128 Mainz, Germany.
Brandon K B SeahMax Planck Institute for Biology, 72076 Tübingen, Germany.ORCID 0000-0002-1878-4363
Falk ButterInstitute of Molecular Biology, 55128 Mainz, Germany.
Mariusz NowackiInstitute of Cell Biology, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0003-4894-2905
Estienne C SwartMax Planck Institute for Biology, 72076 Tübingen, Germany; estienne.swart@tuebingen.mpg.de aditi.singh@tuebingen.mpg.de.ORCID 0000-0002-1362-1602

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the most extensive forms of natural genome editing occurs in ciliates, a group of microbial eukaryotes. Ciliate germline and somatic genomes are contained in distinct nuclei within the same cell. During the massive reorganization process of somatic genome development, ciliates eliminate tens of thousands of DNA sequences from a germline genome copy. Recently, we showed that the chromatin remodeler ISWI1 is required for somatic genome development in the ciliate

Indexed as

Gene EditingGenome, ProtozoanParameciumParamecium tetraureliaProtozoan ProteinsChromatin Assembly and DisassemblyProtozoan Proteins

Identifiers

PMID39542647
PMCPMC11789628

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.