Evidence map›Paper›PMID 39542142›Full record

ReviewThe Journal of allergy and clinical immunology2025

Asthma and respiratory comorbidities.

Dennis K Ledford, Tae-Bum Kim, Victor E Ortega, Juan Carlos Cardet

Abstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dennis K LedfordDepartment of Internal Medicine, Division of Allergy and Immunology, Morsani College of Medicine, University of South Florida, Tampa, and the James A. Haley VA Hospital, Tampa, Fla. Electronic address: dledford@usf.edu.
Tae-Bum KimDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Victor E OrtegaDivision of Pulmonary Medicine, Department of Medicine and Division of Epidemiology, Department of Qualitative Health Sciences, Mayo Clinic School of Health Sciences, Phoenix, Ariz.
Juan Carlos CardetDepartment of Internal Medicine, Division of Allergy and Immunology, Morsani College of Medicine, University of South Florida, Tampa, and the James A. Haley VA Hospital, Tampa, Fla.

Funding

Effects of Rare Variants and Ancestry on Beta Agonist Response in Asthma and COPDR01HL142992 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ORTEGA, VICTOR E. · 2019 to 2023
$3.7M
Social Determinants of Health, Asthma-Related Morbidity and Therapeutic Optimization for Black and Latinx Adults with AsthmaR21HL172124 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI CARDET, JUAN CARLOS · 2024 to 2025
$262k
NHLBI NIH HHS R01 HL142992NHLBI NIH HHS R21 HL172124
6 · The paper itself

Abstract

Asthma is a common respiratory condition with various phenotypes, nonspecific symptoms, and variable clinical course. The occurrence of other respiratory conditions with asthma, or respiratory comorbidities (RCs), is not unusual. A literature search of PubMed was performed for asthma and a variety of respiratory comorbidities for the years 2019 to 2024. The 5 conditions with the largest number of references, other than rhinitis and rhinosinusitis (addressed elsewhere), or that are the most problematic in the authors' clinical experience, are summarized. Others are briefly discussed. The diagnosis and treatment of both asthma and RCs are complicated by the overlap of symptoms and signs. Recognizing RCs is especially problematic in adult-onset, non-type 2 asthma because there are no biomarkers to assist in confirming non-type 2 asthma. Treatment decisions in subjects with suspected asthma and RCs are complicated by the potential similarities between the symptoms or signs of the RC and asthma, the absence of a sine quo non for the diagnosis of asthma, the likelihood that many RCs improve with systemic corticosteroid therapy, and the possibility that manifestations of the RCs are misattributed to asthma or vice versa. Recognition of RCs is critical to the effective management of asthma, particularly severe or difficult-to-treat asthma.

Indexed as

AsthmaRhinitisSinusitisAdrenal Cortex HormonesComorbidityHumansAdrenal Cortex Hormonesallergic bronchopulmonary aspergillosisAsthmaasthma–chronic obstructive pulmonary disease overlapbronchiectasischronic obstructive lung diseasecomorbidcystic fibrosisdiffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)eosinophilic bronchitiseosinophilic pneumonialaryngeal dysfunctionobstructive sleep apnearhinitisrhinosinusitis

Identifiers

PMID39542142
PMCPMC12180284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.