Evidence map›Paper›PMID 39541920›Full record

ArticleCortex; a journal devoted to the study of the nervous system and behavior2024

Emotion-related impulsivity is related to orbitofrontal cortical sulcation.

William L Hastings Iii, Ethan H Willbrand, Joseph P Kelly, Sydney T Washington, Phyllis Tameilau, Reyansh N Sathishkumar, Samira A Maboudian, Benjamin J Parker, Matthew V Elliott, Sheri L Johnson and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Variable Presence of an Evolutionarily New Brain Structure Is Related to Trait Impulsivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

William L Hastings IiiDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA. Electronic address: will.law.hast@berkeley.edu.
Ethan H WillbrandMedical Scientist Training Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: willbrand@wisc.edu.
Joseph P KellyDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, IL USA. Electronic address: josephkelly1@northwestern.edu.
Sydney T WashingtonDepartment of Psychology, California State University, Fullerton, Fullerton, CA, USA. Electronic address: swashington2@csu.fullerton.edu.
Phyllis TameilauDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA. Electronic address: ptameilau7@berkeley.edu.
Reyansh N SathishkumarCognitive Science Program, University of California, Berkeley, Berkeley, CA, USA. Electronic address: sathishkumar@berkeley.edu.
Samira A MaboudianHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA; Department of Neuroscience, University of California, Berkeley, Berkeley, CA, USA. Electronic address: smaboudian@berkeley.edu.
Benjamin J ParkerHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA; Department of Neuroscience, University of California, Berkeley, Berkeley, CA, USA. Electronic address: benparker@berkeley.edu.
Matthew V ElliottDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA. Electronic address: mvelliott@berkeley.edu.
Sheri L JohnsonDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA. Electronic address: sljohnson@berkeley.edu.
Kevin S WeinerDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA; Department of Neuroscience, University of California, Berkeley, Berkeley, CA, USA. Electronic address: kweiner@berkeley.edu.

Funding

Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Neuroscience Training Program at UC BerkeleyT32NS095939 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BATEUP, HELEN S. · 2016 to 2025
$6.3M
TRAINING PROGRAM IN THE NEUROSCIENCE OF HUMAN COGNITIONT32NS047987 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Rodrigo M Braga, Christina Maria Zelano · 2006 to 2026
$5.6M
Stress-Induced Decays in Working Memory and Internalizing SymptomsR01MH110477 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI JOHNSON, SHERI L, TIMPANO, KIARA R · 2016 to 2020
$3.3M
Systematic Identification and Phenotypic Characterization of causal genetic variants in Rare Disease-Associated Birth DefectsR01HD110447 · NICHD · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI Scott T Younger · 2023 to 2026
$2.8M
NICHD NIH HHS R01 HD110447NIGMS NIH HHS T32 GM140935NIMH NIH HHS R01 MH110477NINDS NIH HHS T32 NS047987NINDS NIH HHS T32 NS095939
6 · The paper itself

Abstract

backgroundEmotion-related impulsivity (ERI) describes the trait-like tendency toward poor self-control when experiencing strong emotions. ERI has been shown to be elevated across psychiatric disorders and predictive of the onset and worsening of psychiatric syndromes. Recent work has correlated ERI scores with the region-level neuroanatomical properties of the orbitofrontal cortex (OFC), but not posteromedial cortex (PMC). Informed by a growing body of research indicating that examining the morphology of specific cortical folds (sulci) can produce unique insights into behavioral outcomes, the present study modeled the association between ERI and the morphology of sulci within OFC and PMC, which is a finer scale than previously conducted.

methodsAnalyses were conducted in a transdiagnostic sample of 118 adult individuals with a broad range of psychiatric syndromes. First, we manually defined over 4,000 sulci across 236 cerebral hemispheres. Second, we implemented a model-based LASSO regression to relate OFC sulcal morphology to ERI. Third, we tested whether effects were specific to OFC sulci, sulcal depth, and ERI (as compared to PMC sulci, sulcal gray matter thickness, and non-emotion-related impulsivity).

resultsThe LASSO regression revealed bilateral associations of ERI with the depths of eight OFC sulci. These effects were strongest for OFC sulci, sulcal depth, and ERI in comparison to PMC sulci, sulcal gray matter thickness, and non-emotion-related impulsivity. In addition, we identified a new transverse component of the olfactory sulcus in every hemisphere that is dissociable from the longitudinal component based on anatomical features and correlation with behavior, which could serve as a new transdiagnostic biomarker.

conclusionsThe results of this data-driven investigation provide greater neuroanatomical and neurodevelopmental specificity on how OFC is related to ERI. As such, findings link neuroanatomical characteristics to a trait that is highly predictive of psychopathology.

Indexed as

EmotionsImpulsive BehaviorMagnetic Resonance ImagingPrefrontal CortexAdultFemaleHumansMaleMiddle AgedYoung AdultEmotionMRINeuroanatomyOrbitofrontal cortexPsychopathologySelf-controlTransdiagnostic

Identifiers

PMID39541920
PMCPMC11681932

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.