Evidence map›Paper›PMID 39541522›Full record

Trial reportExperimental and clinical psychopharmacology2025

Residual next-day effects of alprazolam on psychomotor performance and simulated driving in healthy normal adults.

Stevie C Roszkowski, Shanna Babalonis, Marion A Coe, Paul A Nuzzo, Michelle R Lofwall, Laura C Fanucchi, Sharon L Walsh

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Experimental and clinical psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stevie C RoszkowskiCenter on Drug and Alcohol Research, University of Kentucky.
Shanna BabalonisCenter on Drug and Alcohol Research, University of Kentucky.
Marion A Coe
Paul A NuzzoCenter on Drug and Alcohol Research, University of Kentucky.
Michelle R LofwallCenter on Drug and Alcohol Research, University of Kentucky.ORCID 0000-0002-5911-0752
Laura C FanucchiCenter on Drug and Alcohol Research, University of Kentucky.ORCID 0000-0003-0582-2399
Sharon L WalshCenter on Drug and Alcohol Research, University of Kentucky.ORCID 0000-0002-9722-5681

Funding

Research Training in Drug Abuse BehaviorT32DA035200 · NIDA · UNIVERSITY OF KENTUCKY · PI CRAIG R RUSH, William Walton Stoops · 2013 to 2026
$4.4M
Training in Drug Abuse Related Research.T32DA016176 · NIDA · UNIVERSITY OF KENTUCKY · PI DWOSKIN, LINDA P · 2004 to 2020
$4.0M
Exploring New Drug Signals of Abuse in the Human LaboratoryR56DA036635 · NIDA · UNIVERSITY OF KENTUCKY · PI WALSH, SHARON L. · 2015 to 2015
$400k
Alprazolam and Simulated Driving Performance: Next Day EffectsR36DA043714 · NIDA · UNIVERSITY OF KENTUCKY · PI COE, MARION AMANDA · 2017 to 2018
$105k
National Institutes of Health; National Institute on Drug AbuseNIDA NIH HHS R36 DA043714NIDA NIH HHS R56 DA036635NIDA NIH HHS T32 DA016176NIDA NIH HHS T32 DA035200
6 · The paper itself

Abstract

The prevalence of drugged driving has increased in the United States. Some drugged driving may be unintentional as prescription medications used as sleeping aids, like zolpidem, cause impairment after the predicted duration of therapeutic action has elapsed. The aim of this study was to determine if nighttime administration of alprazolam, a drug commonly prescribed off-label as a sleeping aid, impacts driving performance the following day. Participants were healthy adults (

Indexed as

AlprazolamAutomobile DrivingHypnotics and SedativesPsychomotor PerformanceAdultDose-Response Relationship, DrugDouble-Blind MethodFemaleHealthy VolunteersHumansMaleMiddle AgedYoung AdultZolpidemAlprazolamHypnotics and SedativesZolpidem

Identifiers

PMID39541522
PMCPMC12042841

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.