ArticleScience (New York, N.Y.)2024
Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states.
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed.
- Psilocybin as an emerging anxiolytic: mechanisms, evidence, and open questions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Classic Psychedelics for Treating Chronic Pain: Mechanism and Clinical Translation.Molecules (Basel, Switzerland) · 2026Review
- Acute in vivo proximity labeling for membrane targeted proteomics in neuronal circuits.bioRxiv : the preprint server for biology · 2026Article
- Dissociating the Hallucinogenic and Neuroplastic Effects of Psilocybin.bioRxiv : the preprint server for biology · 2026Article
- Activity of VMS-projecting mPFC neurons encodes individual vulnerability to chronic restraint stress in male mice.Neurobiology of stress · 2026Article
- Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation.Molecular psychiatry · 2026Review
- Temporal assessment of behavior in Parkinson's visual hallucinations via a multidimensional analysis strategy.Signal transduction and targeted therapy · 2026Article
- Psilocybin reshapes cortical inhibition through selective interneuron recruitment.bioRxiv : the preprint server for biology · 2026Article
- Psychedelics elicit their effects by 5-HTNature · 2026Article
- Neural signaling mechanisms in depression: bridging classical monoamine hypotheses, animal models, and emerging antidepressant strategies.Frontiers in cell and developmental biology · 2026Review
- The ABCs of psychedelics: a preclinical roadmap for drug discovery.Trends in pharmacological sciences · 2025Review
- Article
- Psychedelics for anxiety disorders: Challenges and opportunities.Fundamental research · 2025Article
- The Medial Prefrontal Cortex Modulates Psychedelic-like Effects of Psilocin.ACS pharmacology & translational science · 2025Article
- The psychedelic-peptide paradox: a hormetic hypothesis.Comprehensive psychoneuroendocrinology · 2025Review
- Narrating the psychoneuroimmunomodulatory properties of serotonin 5-HTActa neuropsychiatrica · 2025Review
- The DRN-VLO pathway via distinct 5-HT synaptic mechanisms modulates neuropathic pain-induced depressive-like behaviors in mice.The journal of headache and pain · 2025Article
- Effects of environmentally-induced anxiety on autoimmunity in the MRL/lpr mouse.Lupus science & medicine · 2025Article
- Role of endogenous serotonin in psychedelic-like effects of psilocybin in mice.The international journal of neuropsychopharmacology · 2025Article
- Cutting-edge methodologies for tagging and tracing active neuronal coding in the brain.Current opinion in neurobiology · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Psychedelics hold promise as alternate treatments for neuropsychiatric disorders. However, the neural mechanisms by which they drive adaptive behavioral effects remain unclear. We isolated the specific neurons modulated by a psychedelic to determine their role in driving behavior. Using a light- and calcium-dependent activity integrator, we genetically tagged psychedelic-responsive neurons in the medial prefrontal cortex (mPFC) of mice. Single-nucleus RNA sequencing revealed that the psychedelic drove network-level activation of multiple cell types beyond just those expressing 5-hydroxytryptamine 2A receptors. We labeled psychedelic-responsive mPFC neurons with an excitatory channelrhodopsin to enable their targeted manipulation. We found that reactivation of these cells recapitulated the anxiolytic effects of the psychedelic without driving its hallucinogenic-like effects. These findings reveal essential insight into the cell-type-specific mechanisms underlying psychedelic-induced behavioral states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.