Evidence map›Paper›PMID 39541236›Full record

ArticleMMWR. Morbidity and mortality weekly report2024

Underutilization of Influenza Antiviral Treatment Among Children and Adolescents at Higher Risk for Influenza-Associated Complications - United States, 2023-2024.

Aaron M Frutos, Haris M Ahmad, Dawud Ujamaa, Alissa C O'Halloran, Janet A Englund, Eileen J Klein, Danielle M Zerr, Melanie Crossland, Holly Staten, Julie A Boom and 46 more

Abstract read
In one paragraph

Article in MMWR. Morbidity and mortality weekly report, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors.

Aaron M Frutos
Haris M Ahmad
Dawud Ujamaa
Alissa C O'Halloran
Janet A Englund
Eileen J Klein
Danielle M Zerr
Melanie Crossland
Holly Staten
Julie A Boom
Leila C Sahni
Natasha B Halasa
Laura S Stewart
Olla Hamdan
Tess Stopczynski
William Schaffner
H Keipp Talbot
Marian G Michaels
John V Williams
Melissa Sutton
M Andraya Hendrick
Mary A Staat
Elizabeth P Schlaudecker
Brenda L Tesini
Christina B Felsen
Geoffrey A Weinberg
Peter G Szilagyi
Bridget J Anderson
Jemma V Rowlands
Murtada Khalifa
Marc Martinez
Rangaraj Selvarangan
Jennifer E Schuster
Ruth Lynfield
Melissa McMahon
Sue Kim
Val Tellez Nunez
Patricia A Ryan
Maya L Monroe
Yun F Wang
Kyle P Openo
James Meek
Kimberly Yousey-Hindes
Nisha B Alden
Isaac Armistead
Suchitra Rao
Shua J Chai
Pam Daily Kirley
Ariana P Toepfer
Fatimah S Dawood
Heidi L Moline
Timothy M Uyeki
Sascha Ellington
Shikha Garg
Catherine H Bozio
Samantha M Olson

Funding

NCIRD CDC HHS U01 IP001152NCIRD CDC HHS U01 IP001156NCIRD CDC HHS U01 IP001158
6 · The paper itself

Abstract

Annually, tens of thousands of U.S. children and adolescents are hospitalized with seasonal influenza virus infection. Both influenza vaccination and early initiation of antiviral treatment can reduce complications of influenza. Using data from two U.S. influenza surveillance networks for children and adolescents aged <18 years with medically attended, laboratory-confirmed influenza for whom antiviral treatment is recommended, the percentage who received treatment was calculated. Trends in antiviral treatment of children and adolescents hospitalized with influenza from the 2017-18 to the 2023-2024 influenza seasons were also examined. Since 2017-18, when 70%-86% of hospitalized children and adolescents with influenza received antiviral treatment, the proportion receiving treatment notably declined. Among children and adolescents with influenza during the 2023-24 season, 52%-59% of those hospitalized received antiviral treatment. During the 2023-24 season, 31% of those at higher risk for influenza complications seen in the outpatient setting in one network were prescribed antiviral treatment. These findings demonstrate that influenza antiviral treatment is underutilized among children and adolescents who could benefit from treatment. All hospitalized children and adolescents, and those at higher risk for influenza complications in the outpatient setting, should receive antiviral treatment as soon as possible for suspected or confirmed influenza.

Indexed as

Antiviral AgentsHospitalizationInfluenza, HumanAdolescentChildChild, PreschoolDrug UtilizationFemaleHumansInfantMaleRisk AssessmentUnited StatesAntiviral Agents

Identifiers

PMID39541236
PMCPMC11576051

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.