ArticleJournal of neurophysiology2024
Input-specific properties of excitatory synapses on oxytocin receptor-expressing neurons in the lateral septum.
Article in Journal of neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oxytocin receptor (OXTR) is expressed in a distinct population of neurons in the lateral septum (LS), among other brain regions, and is responsible for regulating various social and nonsocial behaviors, including reward processing, feeding, social memory, anxiety, and fear. The LS serves as a key link between the cortical and subcortical regions, yet the synaptic inputs that drive the OXTR-expressing LS neurons have not been characterized. Here, we established retrograde and anterograde viral tracing in the mouse brain to map the input connections of the intermediate part of the LS where OXTR neurons are concentrated. Utilizing pathway-specific optogenetic activation, we identified that the strongest cortical inputs to LS OXTR neurons are from the posteromedial amygdala cortex (PMCo) and the ventral hippocampus (vHipp). We further determined that these excitatory inputs exhibit distinct presynaptic and postsynaptic properties, with PMCo synapses displaying a lower release probability and smaller α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-to-
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