Evidence map›Paper›PMID 39541083›Full record

ArticleAdvances in therapy2025

Using Chronic Kidney Disease as a Model Framework to Estimate Healthcare-Related Environmental Impact.

Juan Jose Garcia Sanchez, Katherine A Barraclough, Aleix Cases, Roberto Pecoits-Filho, Celine Germond-Duret, Carmine Zoccali, Nina Embleton, Antony Wright, Luke Hubbert, Lindsay Nicholson and 5 more

Abstract read
In one paragraph

Article in Advances in therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. International Environmental Impact of CKD Care.Kidney international reports · 2026
    Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Juan Jose Garcia SanchezGlobal Market Access and Pricing, AstraZeneca, C/d'Estruc, 9, 08002, Barcelona, Spain. juanjose.garciasanchez@astrazeneca.com.ORCID 0000-0001-6546-7769
Katherine A BarracloughDepartment of Nephrology, Royal Melbourne Hospital, Melbourne, Australia.
Aleix CasesNephrology Unit, Hospital Clínic de Barcelona, Barcelona, Spain.
Roberto Pecoits-FilhoArbor Research Collaborative for Health, Ann Arbor, MI, USA.
Celine Germond-DuretLancaster University, Lancaster, UK.
Carmine ZoccaliUniversita Degli Studi Di Palermo-Facolta Di Medicina E Chirurgia, Palermo, Italy.
Nina EmbletonMaverex Limited, Newcastle upon Tyne, UK.
Antony WrightMaverex Limited, Newcastle upon Tyne, UK.
Luke HubbertMaverex Limited, Newcastle upon Tyne, UK.
Lindsay NicholsonMaverex Limited, Newcastle upon Tyne, UK.
Salvatore BaroneGlobal Medical Affairs, AstraZeneca, Boston, USA.
Nigel BudgenGlobal Safety, Health and Environment, AstraZeneca, Macclesfield, UK.
Claudia CabreraEmerging Medicines, AstraZeneca, Gothenburg, Sweden.
Viknesh SelvarajahResearch and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Matthew J EckelmanDepartment of Civil and Environmental Engineering, Northeastern University, Boston, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWhile the economic and clinical burden of chronic diseases are well documented, their environmental impact remains poorly understood. We developed a framework to estimate the environmental impact of a disease care pathway using chronic kidney disease (CKD) as an example.

methodsA life cycle assessment framework was developed for the CKD care pathway and validated by experts. Life cycle stages were characterised for resource utilisation based on a literature review and ecoinvent database inputs, in ten countries. The ReCiPe impact assessment method was used to calculate impacts across multiple environmental dimensions.

resultsAt CKD stage 5, kidney replacement therapies (KRT) have highest impact; emissions ranged between 3.5 and 43.9 kg carbon dioxide equivalents (CO

conclusionFull care pathways should be analysed alongside specific healthcare processes. Application of this framework enables quantification of the environmental benefits of preventative medicine and effective management of chronic diseases. For CKD, early diagnosis, and proactive management to reduce the need for KRT and hospitalisations could improve patient outcomes and reduce environmental burden.

Indexed as

EnvironmentRenal Insufficiency, ChronicHospitalizationHumansKidney TransplantationRenal DialysisRenal Replacement TherapyCarbon emissionsCare pathwaysChronic kidney diseaseEnvironmental impactGreenhouse gas emissionsHealthcare

Identifiers

PMID39541083
PMCPMC11782431

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.