Evidence map›Paper›PMID 39541066›Full record

ArticleLa Radiologia medica2025

Intravoxel incoherent motion MRI to assess feto-placental diffusion and perfusion properties in small fetuses.

Giada Ercolani, Silvia Capuani, Veronica Celli, Sandra Ciulla, Roberta Ninkova, Marco Gennarini, Valentina Miceli, Robert Grimm, Daniele Di Mascio, Maria Grazia Porpora and 3 more

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Article in La Radiologia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Giada Ercolani *Department of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, "Sapienza" University of Rome, Rome, Italy.
Silvia Capuani *CNR ISC, Physics Department, "Sapienza" University of Rome, Rome, Italy.
Veronica CelliDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, "Sapienza" University of Rome, Rome, Italy.
Sandra CiullaDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, "Sapienza" University of Rome, Rome, Italy.
Roberta NinkovaDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, "Sapienza" University of Rome, Rome, Italy.
Marco GennariniDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, "Sapienza" University of Rome, Rome, Italy.
Valentina MiceliDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, "Sapienza" University of Rome, Rome, Italy.
Robert GrimmSiemens Healthcare GmbH, Erlangen, Germany.
Daniele Di MascioDepartment of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
Maria Grazia PorporaDepartment of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
Antonella GiancottiDepartment of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
Carlo CatalanoDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, "Sapienza" University of Rome, Rome, Italy.
Lucia ManganaroDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, "Sapienza" University of Rome, Rome, Italy. lucia.manganaro@uniroma1.it.ORCID http://orcid.org/0000-0001-9037-9904

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the use of intravoxel incoherent motion (IVIM) to study microperfusion and microstructural characteristics of lungs, brain, and placenta in normal and small fetuses.

methodsWe retrospectively enrolled 30 small fetuses and 82 normal pregnancies who underwent a 1.5-T MRI examination using an IVIM-DWI. Small fetuses were distinguished in small for gestational age (SGA) and "true" fetal growth restriction (FGR). ROIs were placed on the brain parenchyma, lungs, and fetal/maternal placental sides. Differences in perfusion fraction f, diffusion coefficient D, and pseudo-diffusion coefficient D* and their correlation with gestational age (GA) and birth weight (BW) were investigated.

resultsLUNG: f showed significantly lower values (p = 2·10 PLACENTA: FGR showed lower f values than normal ones, in both the fetal (p = 1.4·10 BRAIN: D values in supratentorial white matter (WM) were significantly higher compared to other regions, in both normal and small fetuses. Small fetuses showed higher D values in occipital WM and pons (p = 0.041; p = 0.027) than in normal. D correlates negatively with GA in the healthy group. No correlation between D and GA was found in SGA + FGR group.

conclusionsIn our study, IVIM-MRI allowed us to detect microstructural and microperfusion changes in the placenta, brain, and lung of small fetuses, noninvasively.

Indexed as

Diffusion Magnetic Resonance ImagingFetal Growth RetardationMagnetic Resonance ImagingPlacentaPrenatal DiagnosisAdultBrainFemaleGestational AgeHumansInfant, Small for Gestational AgeLungPregnancyRetrospective StudiesDiffusion magnetic resonance imagingIntrauterine growth restrictionPerfusionPregnancySmall fetus

Identifiers

PMID39541066

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