Evidence map›Paper›PMID 39540929›Full record

ArticleSurgery today2025

Mechanisms of polyglycolic acid sheet-induced abdominal wall adhesions in hamsters.

Shintaro Shigesato, Denan Jin, Wataru Osumi, Kohei Taniguchi, Koji Komeda, Mitsuhiro Asakuma, Hideki Tomiyama, Shinji Takai, Sang-Woong Lee

Abstract read
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In one paragraph

Article in Surgery today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shintaro ShigesatoDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Denan JinDepartment of Innovative Medicine, Graduate School of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.
Wataru OsumiDepartment of Gastroenterology, Otsu City Hospital, Shiga, Japan.
Kohei TaniguchiDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Koji KomedaDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Mitsuhiro AsakumaDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Hideki TomiyamaDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Shinji TakaiDepartment of Innovative Medicine, Graduate School of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan. shinji.takai@ompu.ac.jp.
Sang-Woong LeeDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Osaka, Japan.

Funding

Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (C)/22K06639
6 · The paper itself

Abstract

purposeA hamster adhesion model was used to investigate the mechanism by which polyglycolic acid (PGA) sheets reinforce the surgical site through the acceleration of postoperative adhesion formation.

methodsAfter receiving electrocautery burns on the inside of the abdominal wall, the hamsters were divided into the PGA group (a PGA sheet was placed on the burned area) and a non-treated group (a PGA sheet was not placed). The degree of adhesion was evaluated at 3, 14, 28, and 56 days after burn injury, and the mRNA levels of myeloperoxidase (MPO), tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β1 at the surgical sites were measured.

resultsAdhesion formation was observed 3 days after the burn injury in the non-treated group, but it decreased at 14, 28, and 56 days. On the other hand, a significant increase in adhesion formation was observed at 3 days in the PGA group relative to the non-treated group, with the increase continuing at 14 and 28 days. Significant increases in MPO, TNF-α, and TGF-β1 mRNA levels at the adhesion site were observed 3 days after the burn injury in both groups, with the increase continuing in the PGA group, but not in the non-treated group, at 14 and 28 days.

conclusionsAcceleration of adhesion formation by PGA may be associated with upregulated MPO, TNF-α, and TGF-β1 mRNA levels.

Indexed as

Abdominal WallPolyglycolic AcidPostoperative ComplicationsAnimalsCricetinaeDisease Models, AnimalMaleMesocricetusPeroxidaseRNA, MessengerTime FactorsTissue AdhesionsTransforming Growth Factor beta1Tumor Necrosis Factor-alphaPeroxidasePolyglycolic AcidRNA, MessengerTransforming Growth Factor beta1Tumor Necrosis Factor-alphaAdhesionsHamsterPolyglycolic acid sheetSurgery

Identifiers

PMID39540929

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.