Evidence map›Paper›PMID 39540921›Full record

ArticleDysphagia2025

Time to Onset of Dysphagia Following Head and Neck Radiation.

E Marin Miller, Rameen K Walters, Shaun A Nguyen, Jennifer L Harper, Bradley Depaoli, Ashli K O'Rourke

Abstract read
In one paragraph

Article in Dysphagia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E Marin MillerLangone Health, Department of Otolaryngology - Head and Neck Surgery, New York University, New York, NY, USA.
Rameen K WaltersDepartment of Otolaryngology, Head and Neck Surgery, Temple University, Philadelphia, PA, USA.
Shaun A NguyenDepartment of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
Jennifer L HarperDepartment of Radiation Oncology, Medical University of South Carolina, Charleston, SC, USA.
Bradley DepaoliDepartment of Radiation Oncology, Medical University of South Carolina, Charleston, SC, USA.
Ashli K O'RourkeDepartment of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA. aorourke@musc.edu.ORCID http://orcid.org/0000-0002-1293-501X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the time of onset of dysphagia in a cohort of head and neck cancer patients treated with radiation or chemoradiation. Retrospective chart review of adult patients. 237 patients met inclusion criteria for the study. The average age at cancer diagnosis was 62 years (± 12.6) in a predominantly male cohort (n = 198, 83.5%). The most common subsite was oropharyngeal (n = 146, 60.8%) and squamous cell carcinoma in origin (n = 232, 97.9%). Of head and neck cancer patients diagnosed with new onset dysphagia or a dysphagia related diagnosis, nine (3.8%) were diagnosed at six months to 1 year, 12 (5.1%) at 1-2 years, and 17 (7.1%) at greater than 2 years. The mean radiation dose to the larynx was 43.8 Gy (Gy) (± 14.5) and statistically significant across time the periods (p = 0.018, η2 = 0.161). No difference was found between age, HPV status, T stage, smoking history, or tumor site. The majority of head and neck cancer patients treated with chemoradiation who developed dysphagia did so within the acute time period (during treatment and up to 6 months post treatment). However, a substantial proportion of patients also developed dysphagia in later time periods (16%). The incidence of dysphagia in certain time periods may be impacted by laryngeal radiation dose. Therefore, we recommend long term monitoring/screening of these patients so early intervention can occur.

Indexed as

Deglutition DisordersHead and Neck NeoplasmsRadiation InjuriesAdultAgedAged, 80 and overCarcinoma, Squamous CellChemoradiotherapyFemaleHumansMaleMiddle AgedRetrospective StudiesTime FactorsDysphagiaHead and neck cancerRadiation

Identifiers

PMID39540921
PMCPMC12328464

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.