Evidence map›Paper›PMID 39540716›Full record

ArticleMedical physics2025

4DCT image artifact detection using deep learning.

Joshua W Carrizales, Mattison J Flakus, Dallin Fairbourn, Wei Shao, Sarah E Gerard, John E Bayouth, Gary E Christensen, Joseph M Reinhardt

Abstract read
In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joshua W CarrizalesBiomedical Engineering, University of Iowa, Iowa City, Iowa, USA.
Mattison J FlakusMedical Physics, University of Wisconsin - Madison, Madison, Wisconsin, USA.
Dallin FairbournBiological Engineering, Utah State University, Logan, Utah, USA.
Wei ShaoMedicine, University of Florida, Gainesville, Florida, USA.
Sarah E GerardBiomedical Engineering, University of Iowa, Iowa City, Iowa, USA.
John E BayouthRadiation Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Gary E ChristensenElectrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA.
Joseph M ReinhardtBiomedical Engineering, University of Iowa, Iowa City, Iowa, USA.

Funding

Predicting Pulmonary Function Change to Improve Radiation Planning and OutcomeR01CA166703 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BAYOUTH, JOHN · 2013 to 2017
$1.9M
Iowa Lung Imaging Training ProgramT32HL144461 · NHLBI · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED, REINHARDT, JOSEPH M · 2019 to 2023
$1.6M
NCI NIH HHS R01 CA166703NHLBI NIH HHS T32 HL144461NIH HHS R01 CA166703NIH HHS T32 HL144461
6 · The paper itself

Abstract

backgroundFour-dimensional computed tomography (4DCT) is an es sential tool in radiation therapy. However, the 4D acquisition process may cause motion artifacts which can obscure anatomy and distort functional measurements from CT scans. PURPOSE: We describe a deep learning algorithm to identify the location of artifacts within 4DCT images. Our method is flexible enough to handle different types of artifacts, including duplication, misalignment, truncation, and interpolation.

methodsWe trained and validated a U-net convolutional neural network artifact detection model on more than 23 000 coronal slices extracted from 98 4DCT scans. The receiver operating characteristic (ROC) curve and precision-recall curve were used to evaluate the model's performance at identifying artifacts compared to a manually identified ground truth. The model was adjusted so that the sensitivity in identifying artifacts was equivalent to that of a human observer, as measured by computing the average ratio of artifact volume to lung volume in a given scan.

resultsThe model achieved a sensitivity, specificity, and precision of 0.78, 0.99, and 0.58, respectively. The ROC area-under-the-curve (AUC) was 0.99 and the precision-recall AUC was 0.73. Our model sensitivity is 8% higher than previously reported state-of-the-art artifact detection methods.

conclusionsThe model developed in this study is versatile, designed to handle duplication, misalignment, truncation, and interpolation artifacts within a single image, unlike earlier models that were designed for a single artifact type.

Indexed as

ArtifactsDeep LearningFour-Dimensional Computed TomographyImage Processing, Computer-AssistedHumans4DCTdeep learningmotion artifacts

Identifiers

PMID39540716
PMCPMC11788241

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.