Evidence map›Paper›PMID 39540665›Full record

ArticleHuman brain mapping2024

Evaluation of ComBat Harmonization for Reducing Across-Tracer Differences in Regional Amyloid PET Analyses.

Braden Yang, Tom Earnest, Sayantan Kumar, Deydeep Kothapalli, Tammie Benzinger, Brian Gordon, Aristeidis Sotiras

Abstract read
In one paragraph

Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Braden YangMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0002-2558-4132
Tom EarnestMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0001-8671-8424
Sayantan KumarMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0001-7213-0734
Deydeep KothapalliMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Tammie BenzingerMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0002-8114-0552
Brian GordonMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0003-2109-2955
Aristeidis SotirasMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0003-0795-8820

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
THE XNAT IMAGING INFORMATICS PLATFORMR01EB009352 · NIBIB · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2009 to 2026
$9.3M
21ST CENTURY IMAGING SCIENCES: GRADUATE STUDENT TRAININGT32EB014855 · NIBIB · WASHINGTON UNIVERSITY · PI JOSEPH P CULVER, JOSEPH A O'SULLIVAN · 2012 to 2026
$3.1M
Advanced machine learning algorithms that integrate multi-modal neuroimaging to quantify the heterogeneity in Alzheimer's DiseaseR01AG067103 · NIA · WASHINGTON UNIVERSITY · PI SOTIRAS, ARISTEIDIS · 2021 to 2025
$2.8M
DRIVING PERFORMANCE IN PRECLINICAL ALZHEIMER'S DISEASER01AG043434 · NIA · WASHINGTON UNIVERSITY · PI ROE, CATHERINE M · 2012 to 2016
$2.4M
HIGH PERFORMANCE BIOMEDICAL IMAGING COMPUTER RESOURCESS10RR022984 · NCRR · WASHINGTON UNIVERSITY · PI PRIOR, FRED WILLIAM · 2009 to 2009
$1.9M
GPU COMPUTING RESOURCE TO ENABLE INNOVATION IN IMAGING AND NETWORK BIOLOGYS10OD018091 · OD · WASHINGTON UNIVERSITY · PI PAPPU, ROHIT V, PRIOR, FRED WILLIAM · 2014 to 2014
$598k
Acquisition of a next-generation computing clusterS10OD025200 · OD · WASHINGTON UNIVERSITY · PI TOBIAS, MALCOLM · 2019 to 2019
$597k
BrightFocus Foundation ADRA2021042SNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCRR NIH HHS 1S10RR022984-01A1NCRR NIH HHS S10 RR022984NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS R01 AG043434NIA NIH HHS R01 AG067103NIA NIH HHS R01AG067103NIBIB NIH HHS R01 EB009352NIBIB NIH HHS T32 EB014855NIBIB NIH HHS T32EB014855NIH HHS S10 OD018091NIH HHS S10 OD025200NIH Office of the Director 1S10OD018091-01NIH Office of the Director S10OD025200
6 · The paper itself

Abstract

Differences in amyloid positron emission tomography (PET) radiotracer pharmacokinetics and binding properties lead to discrepancies in amyloid-β uptake estimates. Harmonization of tracer-specific biases is crucial for optimal performance of downstream tasks. Here, we investigated the efficacy of ComBat, a data-driven harmonization model, for reducing tracer-specific biases in regional amyloid PET measurements from [

Indexed as

Aniline CompoundsPositron-Emission TomographyThiazolesAgedAlzheimer DiseaseAmyloid beta-PeptidesBrainEthylene GlycolsFemaleHumansMaleMiddle AgedRadiopharmaceuticals2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloid beta-PeptidesAniline CompoundsEthylene GlycolsflorbetapirRadiopharmaceuticalsThiazolesamyloid‐βCentiloidComBatharmonizationpositron emission tomography

Identifiers

PMID39540665
PMCPMC11561838

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.