The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway.
Cheng Zhong, Shijun Wang, Lei Xia, Xiaoman Yang, Liguang Fang, Xianyi Zhang, Mengyue Wang, Haijun Zhao, Guanghui Wang, Jinglong Wu and 3 more
Article in Cancer biology & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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5 · Who and what money
Authors and funding
13 authors.
Cheng ZhongDepartment of Pathology, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.ORCID 0000-0002-4478-9811
Shijun WangDepartment of Pathology, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.ORCID 0000-0002-5920-4118
Lei XiaDepartment of Pathology, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Xiaoman YangDepartment of Pathology, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Liguang FangDepartment of Pathology, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Xianyi ZhangDepartment of Pathology, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Mengyue WangDepartment of Pathology, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Haijun ZhaoDepartment of Pathology, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Guanghui WangDepartment of Pharmacology and Toxicology, School of Pharmacy, Jining Medical University, Rizhao, China.
Jinglong WuGraduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, Japan.
Ruijian GuoDepartment of Pharmaceutics, College of pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.ORCID 0009-0007-5658-8041
Ming ZhongDepartment of Pharmacology and Toxicology, School of Pharmacy, Jining Medical University, Rizhao, China.ORCID 0000-0002-1869-2901
Eiichi GohdaDivision of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.ORCID 0000-0002-0138-2261
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
The development of an effective treatment for myelodysplastic syndrome (MDS) is needed due to the insufficient efficacy of current therapies. Gambogenic acid (GNA) is a xanthone constituent of gamboge, a resin secreted by
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway. · full record | OpenQuestion