Evidence map›Paper›PMID 39540547›Full record

ArticleFuture medicinal chemistry2024

Design and synthesis of new nicotinamides as immunomodulatory VEGFR-2 inhibitors and apoptosis inducers.

Reda G Yousef, Ibrahim H Eissa, Hazem Elkady, Ahmed B M Mehany, Mariam Ali Abo-Saif, Mohamed M Radwan, Mahmoud A ElSohly, Ibrahim M Ibrahim, Alaa Elwan, Mohamed Ayman El-Zahabi

Abstract read
In one paragraph

Article in Future medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Reda G YousefPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
Ibrahim H EissaPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.ORCID 0000-0002-6955-2263
Hazem ElkadyPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.ORCID 0000-0003-0893-6703
Ahmed B M MehanyZoology Department, Faculty of Science (Boys), Al-Azhar University, Cairo, 11884, Egypt.ORCID 0000-0001-7960-7558
Mariam Ali Abo-SaifBiochemistry Department, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt.ORCID 0000-0001-5531-6588
Mohamed M RadwanNational Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.ORCID 0000-0002-7393-8601
Mahmoud A ElSohlyNational Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.ORCID 0000-0002-0019-2001
Ibrahim M IbrahimBiophysics Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.ORCID 0000-0001-7875-7538
Alaa ElwanPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.ORCID 0000-0003-4270-616X
Mohamed Ayman El-ZahabiPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.ORCID 0000-0003-4538-5840

Funding

Science, Technology & Innovation Funding Authority (STIFA) 43040
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ApoptosisCell ProliferationDrug DesignMolecular Docking SimulationNiacinamideProtein Kinase InhibitorsVascular Endothelial Growth Factor Receptor-2Antineoplastic AgentsCell Line, TumorDrug Screening Assays, AntitumorHumansImmunologic FactorsMolecular Dynamics SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsImmunologic FactorsKDR protein, humanNiacinamideProtein Kinase InhibitorsVascular Endothelial Growth Factor Receptor-2ADMETapoptosisdockingMD simulationnicotinamideVEGFR-2

Identifiers

PMID39540547
PMCPMC11731296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.