Evidence map›Paper›PMID 39540465›Full record

ArticleAnnals of clinical and translational neurology2024

Emergent responsive neurostimulation in pediatric super-refractory epilepsia partialis continua.

Peter N Hadar, Pranav Nanda, Katherine G Walsh, John McLaren, Alexandra Geffrey, Mirela Simon, Kristopher Kahle, R Mark Richardson, Catherine J Chu

Abstract readCase Reports
In one paragraph

Article in Annals of clinical and translational neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peter N HadarDepartment of Neurology, Massachusetts General Hospital (MGH), Boston, Massachusetts, 02114, USA.ORCID 0000-0002-1681-4717
Pranav NandaHarvard Medical School, Boston, Massachusetts, 02115, USA.ORCID 0000-0001-8029-2629
Katherine G WalshDepartment of Neurology, Massachusetts General Hospital (MGH), Boston, Massachusetts, 02114, USA.
John McLarenDepartment of Neurology, Massachusetts General Hospital (MGH), Boston, Massachusetts, 02114, USA.ORCID 0000-0002-4463-9610
Alexandra GeffreyDepartment of Neurology, Massachusetts General Hospital (MGH), Boston, Massachusetts, 02114, USA.
Mirela SimonDepartment of Neurology, Massachusetts General Hospital (MGH), Boston, Massachusetts, 02114, USA.
Kristopher KahleHarvard Medical School, Boston, Massachusetts, 02115, USA.ORCID 0000-0002-5922-7547
R Mark RichardsonHarvard Medical School, Boston, Massachusetts, 02115, USA.ORCID 0000-0003-2620-7387
Catherine J ChuDepartment of Neurology, Massachusetts General Hospital (MGH), Boston, Massachusetts, 02114, USA.ORCID 0000-0001-7670-9313

Funding

Targeting Pathologic Spike-Ripples to Isolate and Disrupt Epileptic DynamicsR01NS119483 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHU, CATHERINE J, EDEN, URI TZVI · 2021 to 2025
$3.4M
NINDS NIH HHS R01 NS119483NINDS NIH HHS R01NS119483
6 · The paper itself

Abstract

Focal status epilepticus, particularly the motor variant of epilepsia partialis continua (EPC), is a rare condition characterized by near-continuous, chronic focal motor seizures, and associated with poor outcomes. Medications, including anesthetics, are often unsuccessful. Surgical resection can result in motor deficits. We report a medically complex pediatric case of super-refractory EPC that was successfully managed with combined focal resection and responsive neuromodulation. This case introduces neuromodulation as a treatment modality for this challenging condition.

Indexed as

Epilepsia Partialis ContinuaChildDrug Resistant EpilepsyElectric Stimulation TherapyFemaleHumans

Identifiers

PMID39540465
PMCPMC11651186

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.