Evidence map›Paper›PMID 39540374›Full record

ArticleMolecular medicine reports2025

PLEKHA4 upregulation regulates KIRC cell proliferation through β‑catenin signaling.

Yuyang Yue, Guangqi An, Shuxia Cao, Xiangdan Li, Liping Du, Dongyuan Xu, Toufeng Jin, Lan Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuyang YueDepartment of Pathology, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China.
Guangqi AnDepartment of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Shuxia CaoKey Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, Jilin 133002, P.R. China.
Xiangdan LiCenter of Morphological Experiment, Medical College of Yanbian University, Yanji, Jilin 133002, P.R. China.
Liping DuDepartment of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Dongyuan XuKey Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, Jilin 133002, P.R. China.
Toufeng JinDepartment of General Surgery, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China.
Lan LiuDepartment of Pathology, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, pleckstrin homology domain‑containing family A member 4 (PLEKHA4) was identified as being upregulated in renal cell carcinoma, particularly within the kidney renal clear cell carcinoma (KIRC) subtype. The present study conducted bioinformatics analysis, Cell Counting Kit‑8 and cell migration assays, flow cytometry, western blotting and

Indexed as

beta CateninCarcinoma, Renal CellCell MovementCell ProliferationGene Expression Regulation, NeoplasticKidney NeoplasmsWnt Signaling PathwayAnimalsCell Line, TumorCyclin D1HumansMaleMiceUp-Regulationbeta CateninCyclin D1kidney renal clear cell carcinomapleckstrin homology domain‑containing family A member 4proliferationβ‑catenin

Identifiers

PMID39540374
PMCPMC11582527

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.