Evidence map›Paper›PMID 39540058›Full record

ArticleBone reports2024

A clinical and molecular characterization of a Pakistani family with multicentric osteolysis, nodulosis and arthropathy (MONA) syndrome.

Safeer Ahmad, Mari Muurinen, Petra Loid, Muhammad Zeeshan Ali, Muhammad Muzammal, Sana Fatima, Jabbar Khan, Muzammil Ahmad Khan, Outi Mäkitie

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Article in Bone reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Safeer AhmadGomal Center of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan, Pakistan.
Mari MuurinenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Petra LoidResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Muhammad Zeeshan AliGomal Center of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan, Pakistan.
Muhammad MuzammalGomal Center of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan, Pakistan.
Sana FatimaGomal Center of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan, Pakistan.
Jabbar KhanInstitute of Biological Sciences, Gomal University, Dera Ismail Khan, Pakistan.
Muzammil Ahmad KhanGomal Center of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan, Pakistan.
Outi MäkitieResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multicentric osteolysis nodulosis and arthropathy (MONA) is a rare skeletal dysplasia characterized primarily by progressive osteolysis, particularly affecting the carpal and tarsal bones, accompanied by osteoporosis. In addition, it features subcutaneous nodules on the palms and soles, along with the progressive onset of arthropathy, encompassing joint contractures, pain, swelling and stiffness. It is caused by a deficiency of the Matrix Metalloproteinase-2 (MMP2). In the current study we present a comprehensive clinical, radiological, genetic and

Indexed as

MMP2Molecular & in silico analysisMONAOsteolysisPakistani family

Identifiers

PMID39540058
PMCPMC11558256

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