ArticleCureus2024
Correlation Between Thrombin Generation and Hepatic Fibrosis in Chronic Liver Diseases.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Thrombin Generation in Acute and Chronic Liver Disease in Children.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic stellate cells (HSC) are recruited to the site of injury in the liver tissue repair mechanism, and the changes HSC undergo reflect paracrine stimulation by all cell types (sinusoidal endothelial cells, Kupffer cells, hepatocytes, platelets, and leukocytes). This study aimed to analyse a possible correlation between the degree of liver fibrosis and thrombin generation in patients with chronic liver diseases. Background Coagulation disorders in patients with chronic liver disease continue to challenge clinicians. A more accurate assessment of the coagulation cascade is provided by investigating thrombin production in individuals with chronic liver disease with varying degrees of fibrosis. Methods This prospective observational pilot study was done on hospitalized patients with chronic liver diseases. Thrombin generation from their platelet-poor plasma was studied and the degree of liver fibrosis assessed by transient elastography versus that of control subjects. Results The peak thrombin is significantly higher in those with severe liver stiffness (F3) than in those with more advanced fibrosis/liver cirrhosis (F4). Also, the total concentration of thrombin formed in the time interval (area under the curve (AUC)) and velocity index (VI) is higher in those with F3 than those with F4. Conclusion Thrombin generation decreases with the progression of liver fibrosis.
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Registered trials
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