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ArticleSovremennye tekhnologii v meditsine2024

Stereotactic Photodynamic Therapy of Recurrent Malignant Gliomas.

A A Rafaelian, B V Martynov, K A Chemodakova, A I Kholyavin, R S Martynov, E Yu Klimenkova, M Yu Prokudin, G V Papayan, I V Boykov, D V Svistov

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In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

A A RafaelianNeurosurgeon, Neurosurgical Department, Neurosurgery Clinic; Military Medical Academy named after S.M. Kirov, 6 Academician Lebedev St., Saint Petersburg, 194044, Russia.
B V MartynovMD, DSc, Associate Professor, Neurosurgeon, Neurosurgical Department, Neurosurgery Clinic; Military Medical Academy named after S.M. Kirov, 6 Academician Lebedev St., Saint Petersburg, 194044, Russia.
K A ChemodakovaNeurosurgeon, Neurosurgical Department, Neurosurgery Clinic; Military Medical Academy named after S.M. Kirov, 6 Academician Lebedev St., Saint Petersburg, 194044, Russia.
A I KholyavinMD, DSc, Neurosurgeon, Neurosurgical Department, Neurosurgery Clinic; Military Medical Academy named after S.M. Kirov, 6 Academician Lebedev St., Saint Petersburg, 194044, Russia; Leading Researcher; Institute of the Human Brain named after N.P. Bekhterevoy, Russian Academy of Sciences, 12A Academician Pavlov St., Saint Petersburg, 197022, Russia.
R S MartynovNeurosurgeon, Neurosurgical Department, Neurosurgery Clinic; Military Medical Academy named after S.M. Kirov, 6 Academician Lebedev St., Saint Petersburg, 194044, Russia.
E Yu KlimenkovaPostgraduate Student, Department of Neurosurgery; Military Medical Academy named after S.M. Kirov, 6 Academician Lebedev St., Saint Petersburg, 194044, Russia.
M Yu ProkudinPhD, Assistant, Department of Nervous Diseases; Military Medical Academy named after S.M. Kirov, 6 Academician Lebedev St., Saint Petersburg, 194044, Russia.
G V PapayanMD, DSc, Senior Researcher, Center for Laser Medicine; Academician I.P. Pavlov First St. Petersburg State Medical University, 6-8 L'va Tolstogo St., Saint Petersburg, 197022, Russia.
I V BoykovMD, DSc, Professor, Deputy Head of the Department of Radiology and Radiology; Military Medical Academy named after S.M. Kirov, 6 Academician Lebedev St., Saint Petersburg, 194044, Russia.
D V SvistovMD, PhD, Associate Professor, Head of the Department of Neurosurgery; Military Medical Academy named after S.M. Kirov, 6 Academician Lebedev St., Saint Petersburg, 194044, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: In a retrospective single-center study the results of sPDT with 5-ALA in 10 patients (6 of 10 were male), aged 30 to 62 years (median: 51.5 years; 95% CI: 38-59 years) with recurrent malignant brain gliomas after standard therapy who underwent surgery during the period of 2020-2023 were analyzed. sPDT was conducted during 15 min using 5-ALA at a dosage of 20 mg/kg, a diode laser with a wavelength of 635 nm and power of 1 W, and the LFT-02-BIOSPEC unit (BIOSPEC, Russia). Three patients got repeated sPDT after 3, 7, and 15 months due to a relapse. The number of target points and the optimal position for intervention paths were determined according to the data of preoperative stereotactic MRI of the brain with contrast intensification using the CRW Precision stereotactic navigation system (Integra, USA) and intraoperative registration of the area with the highest intensity of protoporphyrin IX fluorescence along the path (according to fluorescence biospectroscopy). Results: Glioblastoma (grade IV, WHO) was diagnosed in 7 patients, anaplastic astrocytoma (grade III, WHO) - in 3 persons. Genetic studies were performed for 9 patients, 7 of them had tumors without the Conclusion: The results of a small group of patients allow to consider sPDT with 5-ALA as a promising technique to treat patients with recurrent high-grade gliomas in functionally relevant brain areas and require further prospective assessment.

Indexed as

Aminolevulinic AcidBrain NeoplasmsGliomaNeoplasm Recurrence, LocalPhotochemotherapyAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPhotosensitizing AgentsRetrospective StudiesStereotaxic TechniquesTreatment OutcomeAminolevulinic AcidPhotosensitizing AgentsglioblastomaIDH1 gene mutationinterstitial photodynamic therapymalignant gliomasrelapse of glioblastomastereotaxis

Identifiers

PMID39539750
PMCPMC11556050

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.