Evidence map›Paper›PMID 39539545›Full record

ArticleFrontiers in immunology2024

CRISPR/Cas9-mediated knockout of STAT1 in porcine-derived cell lines to elucidate the role of STAT1 in autophagy following classical swine fever virus infection.

Liyuan Zhang, Dongli Liang, Kaijun Min, Jiaxin Liang, Yu Tian, Cheng Liu, Ting Rong Luo, Xiaoning Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Biological Role and Clinical Significance of BECLIN-1 in Cancer.International journal of molecular sciences · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liyuan ZhangCollege of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, Guangxi, China.
Dongli LiangCollege of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, Guangxi, China.
Kaijun MinCollege of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, Guangxi, China.
Jiaxin LiangCollege of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, Guangxi, China.
Yu TianCollege of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, Guangxi, China.
Cheng LiuCollege of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, Guangxi, China.
Ting Rong LuoCollege of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, Guangxi, China.
Xiaoning LiCollege of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, Guangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Signal transducer and activator of transcription 1 (STAT1) plays a critical role in immune response, human STAT1 as a transcriptional suppressor of autophagy genes and autophagic activity. Classical swine fever virus (CSFV)-infected induce autophagy, leading to immune evasion. However, there are limited reports on the function of porcine STAT1 in autophagy during CSFV infection. There is also lack of suitable

Indexed as

AutophagyClassical Swine FeverClassical Swine Fever VirusCRISPR-Cas SystemsGene Knockout TechniquesSTAT1 Transcription FactorAnimalsCell LineGene EditingSwineSTAT1 Transcription FactorautophagyCRISPR/Cas9 (Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems)CSFV (Classical swine fever virus)gene knockout cell linesSTAT1 (Signal transducers and activators of transcription 1)ULK1

Identifiers

PMID39539545
PMCPMC11557322

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.