Evidence map›Paper›PMID 39539530›Full record

ArticleRSC advances2024

Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABA

Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F Zorumski, Alex S Evers, Steven Mennerick, Douglas F Covey

Abstract read
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. New directions in neurosteroid therapeutics in neuropsychiatry.Neuroscience and biobehavioral reviews · 2025
    Review
  3. Neurosteroids: a lifelong impact on brain health.Frontiers in behavioral neuroscience · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mingxing QianDepartment of Developmental Biology, Washington University in St. Louis 660 S. Euclid Ave. St. Louis MO 63110 USA dcovey@wustl.edu.
Yuanjian XuDepartment of Developmental Biology, Washington University in St. Louis 660 S. Euclid Ave. St. Louis MO 63110 USA dcovey@wustl.edu.
Hong-Jin ShuDepartment of Psychiatry, Washington University in St. Louis 660 S. Euclid Ave. St. Louis MO 63110 USA.
Zi-Wei ChenDepartment of Anesthesiology, Washington University in St. Louis 660 S. Euclid Ave. St. Louis MO 63110 USA.
Lei WangDepartment of Anesthesiology, Washington University in St. Louis 660 S. Euclid Ave. St. Louis MO 63110 USA.
Charles F ZorumskiDepartment of Psychiatry, Washington University in St. Louis 660 S. Euclid Ave. St. Louis MO 63110 USA.
Alex S EversDepartment of Developmental Biology, Washington University in St. Louis 660 S. Euclid Ave. St. Louis MO 63110 USA dcovey@wustl.edu.
Steven MennerickDepartment of Psychiatry, Washington University in St. Louis 660 S. Euclid Ave. St. Louis MO 63110 USA.
Douglas F CoveyDepartment of Developmental Biology, Washington University in St. Louis 660 S. Euclid Ave. St. Louis MO 63110 USA dcovey@wustl.edu.ORCID https://orcid.org/0000-0002-9316-8683

Funding

Neuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI COVEY, DOUGLAS F · 2021 to 2025
$12.2M
MOLECULAR SITES OF NEUROSTEROID BINDINGR01GM108799 · NIGMS · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2014 to 2022
$4.0M
Neurosteroid and Cholesterol Binding to Integral Membrane ProteinsR35GM149287 · NIGMS · WASHINGTON UNIVERSITY · PI ALEX S. EVERS · 2023 to 2026
$2.4M
GABAA RECEPTOR POPULATIONS IN HIPPOCAMPUS AND THALAMUSR01MH123748 · NIMH · WASHINGTON UNIVERSITY · PI MENNERICK, STEVEN J · 2021 to 2025
$2.4M
Development of chemical biology tools for NMDA receptorsR01MH110550 · NIMH · WASHINGTON UNIVERSITY · PI COVEY, DOUGLAS F · 2017 to 2021
$2.0M
NIGMS NIH HHS R01 GM108799NIGMS NIH HHS R35 GM149287NIMH NIH HHS P50 MH122379NIMH NIH HHS R01 MH110550NIMH NIH HHS R01 MH123748
6 · The paper itself

Abstract

The endogenous neurosteroids dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate (PS) are allosteric modulators of γ-aminobutyric acid type A (GABA

Identifiers

PMID39539530
PMCPMC11559520

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.