Evidence map›Paper›PMID 39539508›Full record

ArticleRoyal Society open science2024

Enhancement of reactive oxygen species production by ultra-short electron pulses.

J Tye, O Solgaard, R J England, J V Trapp, A Fielding, C P Brown

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Royal Society open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J TyeMMPE, Faculty of Engineering, Queensland University of Technology, Brisbane, Queensland, Australia.
O SolgaardEdward L. Ginzton Laboratory, Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
R J EnglandSLAC National Accelerator Laboratory, Menlo Park, CA, USA.
J V TrappSchool of Chemistry and Physics, Faculty of Science, Queensland University of Technology, Brisbane, Queensland, Australia.
A FieldingCentre for Biomedical Technology, Queensland University of Technology, Brisbane, Queensland, Australia.
C P BrownMMPE, Faculty of Engineering, Queensland University of Technology, Brisbane, Queensland, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of laser-driven accelerators-on-chip has provided an opportunity to miniaturize devices for electron radiotherapy delivery. Laser-driven accelerators produce highly time-compressed electron pulses, on the 100 fs to 1 ps scale. This delivers electrons at high peak power yet low average beam current compared with conventional delivery devices, which generate pulses of approximately 3 µs. The biophysical effects of this time structure, however, are unclear. Here, we use a Monte Carlo simulation approach to explore the effects of the electron beam time structure on the production of reactive oxygen species (ROS) in water. Our results show a power law increase in the generation of hydroxyl ions per deposited electron with decreasing pulse length over the pulse length range of 10 µs to 100 fs. Similar trends were observed for hydrogen peroxide, superoxide, hydroperoxyl, hydronium and solvated electrons. In practical terms, this indicates a fourfold increase in the efficiency of free radical production for sub-picosecond pulses, relative to that of conventional microsecond pulses, for the same number of deposited electrons.

Indexed as

dielectric laser acceleratorelectron radiotherapyelectron-tissue interactionpulse durationreactive oxygen species

Identifiers

PMID39539508
PMCPMC11557238

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.