Evidence map›Paper›PMID 39539495›Full record

ArticleFrontiers in neuroscience2024

Case report: Double mutations in a patient with early-onset Alzheimer's disease in China, PSEN2 and IDE variants.

Zhongzheng Chang, Zhiyang Wang, Lele Luo, Zhaohong Xie, Caibin Yue, Xianli Bian, Hui Yang, Ping Wang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. The Role ofNutrients · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhongzheng ChangDepartment of Neurology, the Second Hospital of Shandong University, Jinan, China.
Zhiyang WangCheeloo College of Medicine, Shandong University, Jinan, China.
Lele LuoCheeloo College of Medicine, Shandong University, Jinan, China.
Zhaohong XieDepartment of Neurology, the Second Hospital of Shandong University, Jinan, China.
Caibin YueDepartment of Infectious Diseases and Hepatology, the Second Hospital of Shandong University, Jinan, China.
Xianli BianDepartment of Neurology, the Second Hospital of Shandong University, Jinan, China.
Hui Yang *Department of Neurology, the Second Hospital of Shandong University, Jinan, China.
Ping Wang *Department of Neurology, the Second Hospital of Shandong University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by gradual cognitive decline. Early-onset Alzheimer's disease (EOAD) is defined as AD occurring before age 65. The main pathogenic gene variants associated with EOAD include

Indexed as

Alzheimer’s diseaseEOADIDEmissense mutationPSEN2

Identifiers

PMID39539495
PMCPMC11557526

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.