ArticleIranian journal of basic medical sciences2024
Genistein inhibits the release of pro-inflammatory substances from macrophages by suppressing potassium loss- and ROS-mediated caspase-1/gasdermin D pathway activation and pyroptotic cell lysis.
Article in Iranian journal of basic medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Involvement of the pyroptosis-HMGB1 axis in systemic diseases.Frontiers in cell and developmental biology · 2026Review
- Gypenosides alleviates MCT-induced pulmonary arterial hypertension in rats by targeting oxidative stress, inflammation, and apoptosis.Iranian journal of basic medical sciences · 2025Article
- Mechanistic insights into adipose-derived stem cells and exosomes in ischemia-reperfusion injury repair: from shared pathways to organ-specific therapeutics.Frontiers in cell and developmental biology · 2025Review
- Beyond Hormone Replacement: Multifaceted Effects of Phytoestrogens for Optimizing Kinesiological and Physiological Adaptations in Postmenopausal Women.Clinical interventions in aging · 2025Review
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Authors and funding
2 authors.
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Abstract
Objectives: The expression of pro-inflammatory substances is closely related to various diseases. Genistein (GEN), a soy isoflavone, has been proven to inhibit the production of pro-inflammatory substances in macrophages. This study aimed to determine whether GEN exerts its inhibitory effect on the expression of pro-inflammatory substances by suppressing the release of these substances via attenuating pyroptotic cell lysis. Materials and Methods: Mice were treated with lipopolysaccharide (LPS) and GEN. J774A.1 cells were treated with LPS, adenosine triphosphate (ATP), and GEN. The expression of pro-inflammatory cytokines and high mobility group box 1 (HMGB1) was measured by qRT-PCR and ELISA. The activation of caspase-1 (CASP1) and cleavage of gasdermin D (GSDMD) were determined by Western blot assay. Lactic dehydrogenase (LDH) assay and CCK8 assay were performed to determine the integrity of the cell membrane and cell viability. The concentration of intracellular potassium (K Results: GEN inhibited the production of IL-1β and HMGB1 in LPS-challenged mice and LPS+ATP-treated mouse macrophages by inhibiting GSDMD-mediated pyroptotic cell lysis. Mechanistically, GEN could prevent the loss of intracellular K Conclusion: GEN inhibits CASP1/GSDMD-mediated pyroptotic cell lysis and the following release of pro-inflammatory substances by suppressing K
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