ArticleJournal of rehabilitation medicine2024
Paired associative stimulation improves motor function in the upper extremity in chronic incomplete spinal cord injury: a corroborative study.
Article in Journal of rehabilitation medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Paired associative stimulation improves outcomes when applied at the subacute stage after incomplete cervical spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Observation on the efficacy of combined electrical stimulation in the treatment of incomplete spinal cord injury: a randomized controlled trial.Frontiers in neurologyTrial
- Improving hand function in chronic incomplete tetraplegia by high-PAS intervention with alternative equipment: a case report.Spinal cord series and cases · 2026Article
- Heart rate variability in patients with incomplete spinal cord injury during a single session of paired associative stimulation.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo corroborate findings suggesting that spinally targeted paired associative stimulation improves upper extremity motor function in chronic incomplete spinal cord injury.
designProspective interventional study. SUBJECTS: Five adults with chronic tetraplegia.
methodsParticipants received paired associative stimulation, combining peripheral nerve stimulation and navigated transcranial magnetic stimulation towards 1 arm (16 1-h sessions during 4 consecutive weeks, targeting the 3 large nerves). Manual muscle testing (MMT) was performed in 23 muscles in each arm, at 3 time points (pre-stimulation, t0; the week following the stimulation period, t1; and 4-5 weeks post-stimulation, t2). Additionally, grip strength and changes in the Canadian Occupational Performance Measure were assessed.
resultsThe mean improvement in manual muscle testing scores in the targeted extremity was +0.49 at t1 (p = 0.078) and +0.55 at t2 (p = 0.062). Grip strength in the stimulated extremity increased by 3.2 kg at t1 and 3.4 kg at t2, and in the non-targeted extremity by 2.2 and 3.6 kg, respectively. Performance and satisfaction increased by 2.1/2.4 points at t1, and by 2.0/1.9 points at t2.
conclusionPaired associative stimulation improved motor function: at the group level, MMT of the stimulated hand (p = 0.06) and non-stimulated hand (p = 0.04). Most participants achieved clinically relevant improvement. Thus, the results corroborate prior studies. The method may complement conventional rehabilitation for improving upper extremity function in incomplete tetraplegia.
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