ArticleThe Plant cell2024
VvFHY3 links auxin and endoplasmic reticulum stress to regulate grape anthocyanin biosynthesis at high temperatures.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Spatial control of anthocyanin and proanthocyanidin production in tomato fruits by competitive MBW complexes to promote seed dispersal.Plant communications · 2026Article
- Light Regulation of Anthocyanin Biosynthesis in Plants: From Mechanisms to Applications.Plant, cell & environment · 2026Review
- Unraveling competitive protein interactions: A critical step toward improved production and therapeutics.Journal of advanced research · 2026Review
- Plant Flavonoids: Biosynthesis, Regulation, and Roles in Biotic and Abiotic Stresses.Plant, cell & environment · 2026Review
- Engineering climate-resilient horticultural crops: advances in transcriptional regulation, genome editing, and synthetic networks.Horticulture research · 2026Article
- Genetic and Transcriptomic Analyses of the Purple Coloration Trait in the Inbred Line 7A01 ofPlants (Basel, Switzerland) · 2026Article
- Transcription factor MdMYB6L represses anthocyanin biosynthesis of apple skin at low-altitude regions.Plant cell reports · 2026Article
- Genome-Wide Analysis Reveals the Roles ofInternational journal of molecular sciences · 2026Article
- Environmental control of anthocyanin biosynthesis in mulberry: unraveling gene networks for food applications.Food chemistry. Molecular sciences · 2026Review
- Genome-Wide Identification and Analysis of BAHD Acyltransferases Involved in Anthocyanin Biosynthesis inBiology · 2026Article
- More than a defense: salicylic acid's secret role in fruit color.The Plant cell · 2026Article
- The PrFRS2-PrMYB75a module regulates petal coloration in flare tree peony (Horticulture research · 2026Article
- Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018.Current Alzheimer research · 2026Article
- Molecular mechanisms of phytohormone ABA-regulated anthocyanin biosynthesis in grape berry: an epigenetic dual-gating hypothesis within a five-layer regulatory framework.Frontiers in molecular biosciences · 2026Review
- Transcriptome analysis and functional validation reveal that VvMYB1 is a positive regulator of drought tolerance in grape.Frontiers in plant science · 2026Article
- Anthocyanins in woody ornamental plants: biosynthesis, regulatory networks, and trade-offs in stress adaptation.Frontiers in plant science · 2026Review
- bZIP factors of the Unfolded Protein Response interact with PIF4 to promote thermomorphogenesis.Nature communications · 2025Article
- Identification of the BBX gene family and SmBBX5 positively regulate anthocyanin accumulation in eggplant (Solanum melongena L.).BMC genomics · 2025Article
- Article
- Fine-Mapping ofBiology · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
Anthocyanins affect quality in fruits such as grape (Vitis vinifera). High temperatures reduce anthocyanin levels by suppressing the expression of anthocyanin biosynthesis genes and decreasing the biosynthetic rate. However, the regulatory mechanisms that coordinate these 2 processes remain largely unknown. In this study, we demonstrate that high-temperature-mediated inhibition of anthocyanin biosynthesis in grape berries depends on the auxin and endoplasmic reticulum (ER) stress pathways. Inactivation of these pathways restores anthocyanin accumulation under high temperatures. We identified and characterized FAR-RED ELONGATED HYPOCOTYL3 (FHY3), a high-temperature-modulated transcription factor that activates multiple anthocyanin biosynthesis genes by binding to their promoters. The auxin response factor VvARF3 interacts with VvFHY3 and represses its transactivation activity, antagonizing VvFHY3-induced anthocyanin biosynthesis. Additionally, we found that the ER stress sensor VvbZIP17 represses anthocyanin biosynthesis. VvFHY3 suppresses VvbZIP17 activity by directly binding to the VvbZIP17 promoter to repress its transcription and by physically interacting with VvbZIP17 to block its DNA binding ability. Furthermore, AUXIN RESPONSE FACTOR 3 (ARF3) interferes with the VvFHY3-VvbZIP17 interaction, releasing VvbZIP17 to activate the unfolded protein response and further suppress anthocyanin production. Our results unravel the VvARF3-VvFHY3-VvbZIP17 regulatory module, which links the auxin and ER stress pathways to coordinately repress anthocyanin structural gene expression and biosynthesis under high-temperature stress.
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