Evidence map›Paper›PMID 39539030›Full record

Trial reportHuman vaccines & immunotherapeutics2024

A randomized clinical trial of the impact of melatonin on influenza vaccine: Outcomes from the melatonin and vaccine response immunity and chronobiology study (MAVRICS).

Rachel U Lee, Nora L Watson, Gena L Glickman, Lindsey White, Sandra D Isidean, Chad K Porter, Monique Hollis-Perry, Samuel R Walther, Santina Maiolatesi, Martha Sedegah and 13 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Human vaccines & immunotherapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Rachel U LeeDepartment of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Nora L WatsonDepartment of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Gena L GlickmanDepartment of Psychiatry and Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Lindsey WhiteHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Sandra D IsideanHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Chad K PorterDepartment of Translational and Clinical Research, Naval Medical Research Command, Silver Spring, MD, USA.
Monique Hollis-PerryDepartment of Psychiatry and Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Samuel R WaltherDepartment of Translational and Clinical Research, Naval Medical Research Command, Silver Spring, MD, USA.
Santina MaiolatesiHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Martha SedegahDepartment of Translational and Clinical Research, Naval Medical Research Command, Silver Spring, MD, USA.
Harini GaneshanHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Jun HuangHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
David A BoulifardHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Daniel EwingDepartment of Translational and Clinical Research, Naval Medical Research Command, Silver Spring, MD, USA.
Appavu K SundaramDepartment of Translational and Clinical Research, Naval Medical Research Command, Silver Spring, MD, USA.
Elizabeth M HarrisonDepartment of Psychiatry and Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Katherine DeTizioHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Maria BelmonteHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Arnel BelmonteDepartment of Translational and Clinical Research, Naval Medical Research Command, Silver Spring, MD, USA.
Sandra InoueDepartment of Translational and Clinical Research, Naval Medical Research Command, Silver Spring, MD, USA.
Alexandra EasterlingHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Elizabeth S CooperDepartment of Translational and Clinical Research, Naval Medical Research Command, Silver Spring, MD, USA.
Janine DankoDepartment of Translational and Clinical Research, Naval Medical Research Command, Silver Spring, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccine immunogenicity is affected by a variety of factors. Melatonin has been reported to affect immune responses to vaccines and infection. This was a randomized open-label trial - in which adults scheduled to receive the influenza vaccine were randomized to 5 mg melatonin or control to evaluate the effect of post-vaccination melatonin on humoral (hemagglutination-inhibition assays, HAI) and cellular (FluoroSpot) vaccine-specific cytokine responses 14-21 days post-vaccination. A total of 108 participants (melatonin treatment group: 53; control group: 55) completed the study. The groups were similar in baseline characteristics, including sleep as measured by the Pittsburgh Sleep Quality Index. Seroconversion rates or geometric mean fold rises (GMFR) in HAI titers did not vary by treatment group. There were also no statistically significant differences between pre- and post-vaccination levels of interferon gamma (IFN-γ) or granzyme B (GzB) by treatment; however, there was a significantly higher fold rise in the double secretor (IFN-γ + GzB) peripheral blood mononuclear cells for influenza vaccine in subjects taking daily melatonin (GMFR 1.7; 95% CI 1.3, 2.3) compared to those who did not (GMFR 0.9; 95% CI 0.7, 1.1) (

Indexed as

Antibodies, ViralHemagglutination Inhibition TestsInfluenza VaccinesMelatoninAdultCytokinesFemaleGranzymesHumansImmunity, CellularImmunity, HumoralImmunogenicity, VaccineInfluenza, HumanInterferon-gammaLeukocytes, MononuclearMaleAntibodies, ViralCytokinesGranzymesInfluenza VaccinesInterferon-gammaMelatonincellular immunityhumoral immunityinfluenza vaccinemelatoninvaccine adjuvantVaccine immunogenicity

Identifiers

PMID39539030
PMCPMC11572083

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.