Evidence map›Paper›PMID 39538979›Full record

Observational studyThe journals of gerontology. Series A, Biological sciences and medical sciences2024

Diagnostic Power of Serum Creatinine/Cystatin C Ratio for Identifying Low MRI-Muscle Volume and Low Grip Strength: Data From 9 731 to 149 707 UK Biobank Older Adults.

Ben Kirk, Chia-Ling Kuo, Peiran Liu, Meiruo Xiang, Jesse Zanker, Konstantinos Prokopidis, Marc Sim, Richard H Fortinsky, George A Kuchel, Gustavo Duque

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ben KirkDepartment of Medicine, Western Health, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-0176-776X
Chia-Ling KuoThe Cato T. Laurencin Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, Connecticut, USA.ORCID 0000-0003-4452-2380
Peiran LiuThe Cato T. Laurencin Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, Connecticut, USA.
Meiruo XiangThe Cato T. Laurencin Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, Connecticut, USA.
Jesse ZankerDepartment of Medicine, Western Health, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-3463-6827
Konstantinos ProkopidisDepartment of Musculoskeletal Biology, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.ORCID 0000-0002-6264-9388
Marc SimNutrition and Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.ORCID 0000-0001-5166-0605
Richard H FortinskyUConn Center on Aging, University of Connecticut, Farmington, Connecticut, USA.
George A KuchelUConn Center on Aging, University of Connecticut, Farmington, Connecticut, USA.
Gustavo DuqueBone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0001-8126-0637

Funding

Research Education ComponentP30AG067988 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Richard H Fortinsky, GEORGE A KUCHEL · 2021 to 2026
$9.5M
Claude D. Pepper Older American Independence Centers P30AG067988Future Health Research and Innovation FundNIA NIH HHS P30 AG067988Royal Perth Hospital Research Foundation
6 · The paper itself

Abstract

backgroundBiomarkers for sarcopenia are lacking. We examined the diagnostic power of serum creatinine to cystatin C ratio for identifying low magnetic resonance imaging-muscle volume and low grip strength in a large observational study of UK Biobank older adults.

methodsSerum creatinine and cystatin C were measured via immunoassays (Beckman Coulter AU5800 and Siemens Advia 1800, respectively) and grip strength by hydraulic hand dynamometer at baseline visit (2008-2010). magnetic resonance imaging-thigh fat-free muscle volume and DXA-derived appendicular lean mass were measured at imaging visit (2014-2018). Extreme outliers were removed, and covariates (demographic, lifestyle, and clinical factors, as well as time elapsed between baseline-imaging visit) were adjusted for in statistical models.

results12 873 older adults (mean age: 63.5 ± 2.7 years, 44.2% women) were included for fat-free muscle volume and appendicular lean mass/body mass index; 149 707 older adults (mean age: 64.0 ± 2.9 years, 50.5% women) for grip strength. Despite significant associations (p < .05), in fully adjusted models, creatinine to cystatin C showed poor to acceptable diagnostic power for identifying low fat-free muscle volume when using cutpoints of 20th percentile (area under the curve: 0.577 men; 0.622 women) and T scores of -2 (area under the curve: 0.596 men; 0.659 women) and -2.5 (area under the curve: 0.609 men; 0.722 women). In fully adjusted model, creatinine to cystatin C showed poor diagnostic power (area under the curves: <0.70) for identifying low appendicular lean mass/body mass index or low grip strength, irrespective of the cutpoint used.

conclusionsCreatinine to cystatin C may not be a suitable biomarker for identifying low muscle volume or low strength in older adults. This finding, drawn from a large sample size and the use of advanced medical imaging, marks an important contribution to the sarcopenia field.

Indexed as

BiomarkersCreatinineCystatin CHand StrengthMagnetic Resonance ImagingMuscle, SkeletalSarcopeniaAgedBiological Specimen BanksFemaleHumansMaleMiddle AgedUK BiobankUnited KingdomBiomarkersCreatinineCystatin CBiomarkersMedical ImagingSarcopeniaSkeletal Muscle

Identifiers

PMID39538979
PMCPMC11655890

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.