Evidence map›Paper›PMID 39538341›Full record

ArticleAnimal microbiome2024

Changes in social environment impact primate gut microbiota composition.

Colleen S Pearce, Danielle Bukovsky, Katya Douchant, Abhay Katoch, Jill Greenlaw, Daniel J Gale, Joseph Y Nashed, Don Brien, Valerie A Kuhlmeier, Mark A Sabbagh and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal microbiome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Colleen S PearceCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Danielle BukovskyDepartment of Psychology, Queen's University, Kingston, ON, Canada.
Katya DouchantCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Abhay KatochDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Jill GreenlawDepartment of Medicine, Queen's University, Kingston, ON, Canada.
Daniel J GaleCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Joseph Y NashedCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Don BrienCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Valerie A KuhlmeierCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Mark A SabbaghCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Gunnar BlohmCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Fernanda G De FeliceCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Martin PareCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Douglas J CookCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Stephen H ScottCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Douglas P MunozCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Calvin P SjaardaCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Anita TuscheCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Prameet M ShethCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Andrew WinterbornCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Susan BoehnkeCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Jason P GallivanCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada. gallivan@queensu.ca.

Funding

New Frontiers in Research Fund NFREF-2021-00936
6 · The paper itself

Abstract

backgroundThe gut microbiota (GM) has proven to be essential for both physical health and mental wellbeing, yet the forces that ultimately shape its composition remain opaque. One critical force known to affect the GM is the social environment. Prior work in humans and free-ranging non-human primates has shown that cohabitation and frequent social interaction can lead to changes in GM composition. However, it is difficult to assess the direction of causation in these studies, and interpretations are complicated by the influence of uncontrolled but correlated factors, such as shared diet.

resultsWe performed a 15-month longitudinal investigation wherein we disentangled the impacts of diet and social living conditions on GM composition in a captive cohort of 13 male cynomolgus macaques. The animals were in single housing for the first 3 months of the study initially with a variable diet. After baseline data collection they were placed on a controlled diet for the remainder of the study. Following this diet shift the animals were moved to paired housing for 6 months, enabling enhanced social interaction, and then subsequently returned to single housing at the end of our study. This structured sequencing of diet and housing changes allowed us to assess their distinct impacts on GM composition. We found that the early dietary adjustments led to GM changes in both alpha and beta diversity, whereas changes in social living conditions only altered beta diversity. With respect to the latter, we found that two particular bacterial families - Lactobacillaceae and Clostridiaceae - demonstrated significant shifts in abundance during the transition from single housing to paired housing, which was distinct from the shifts we observed based on a change in diet. Conversely, we found that other bacteria previously associated with sociality were not altered based on changes in social living conditions but rather only by changes in diet.

conclusionsTogether, these findings decouple the influences that diet and social living have on GM composition and reconcile previous observations in the human and animal literatures. Moreover, the results indicate biological alterations of the gut that may, in part, mediate the relationship between sociality and wellbeing.

Indexed as

Gut microbiotaMetagenomicsMonkeysPrimatesSocial environmentSocial living

Identifiers

PMID39538341
PMCPMC11562706

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.