Evidence map›Paper›PMID 39538139›Full record

Trial reportBMC cardiovascular disorders2024

Guideline-directed antihypertensive medication use among young adult participants with uncontrolled hypertension at enrollment in the MyHEART study.

Megan R Knutson Sinaise, Jennifer Zaborek, KyungMann Kim, Diane R Lauver, Patrick McBride, Jane Pearson, Allexa Licon, Anupama Joseph, Heather M Johnson, Kara K Hoppe

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03158051 (The MyHEART Study), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03158051 nacompletednot on this map

The MyHEART Study: A Young Adult Hypertension Self-Management Randomized Controlled Trial

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2017 to 2022Enrolled316ConditionsHypertension, Blood Pressure, Lifestyle Risk ReductionArmsHome Blood Pressure Monitoring, Telephone Health Coaching
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Megan R Knutson SinaiseDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, McConnell Hall, 1010 Mound Street, Madison, WI, 53715, USA. mknutson2@wisc.edu.
Jennifer ZaborekDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
KyungMann KimDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
Diane R LauverSchool of Nursing and School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Patrick McBrideDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Jane PearsonDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Allexa LiconDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Anupama JosephDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Heather M JohnsonChristine E Lynn Women's Health & Wellness Institute, Baptist Health South Florida, Boca Raton, FL, USA.
Kara K HoppeDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, McConnell Hall, 1010 Mound Street, Madison, WI, 53715, USA.

Funding

The MyHEART Study: A Young Adult Hypertension Self-Management Randomized Controlled TrialR01HL132148 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI HOPPE, KARA K · 2017 to 2021
$3.4M
NHLBI NIH HHS R01 HL132148NHLBI NIH HHS R01HL132148
6 · The paper itself

Abstract

backgroundHypertension is a major risk factor for heart disease, heart failure and stroke. Lifestyle changes are recommended as first-line treatment for management of high blood pressure for young adults, when 10-year atherosclerotic cardiovascular disease risk score is < 10%. If lifestyle changes alone do not control blood pressure, then providers have access to four classes of first-line blood pressure lowering agents to treat hypertension, when other contra-indications are not present.

methodsThis is a cross-sectional, retrospective, secondary analysis performed of the MyHEART trial on study participants at enrollment to determine they were prescribed anti-hypertensive medication. Of those prescribed medications, we aimed to determine the frequency first-line medications including thiazide or thiazide-like diuretics, angiotensin converting-enzyme inhibitors, angiotensin receptor blockers, and calcium channel blockers were prescribed. This analysis categorized participants into four medication status categories: no antihypertensive medication, prescribed only first-line antihypertensives, prescribed only non-first-line antihypertensives, and prescribed a combination of first-line and non-first-line antihypertensives. Participant clinical and sociodemographic factors by medication use were evaluated. Linear regression models were fit to determine the association between antihypertensive medication and blood pressure.

resultsAt enrollment, 157/311 (50.5%) participants were not on antihypertensives. Of the 154 on antihypertensives, reported use included monotherapy 97/154 (63.0%), combined therapy 57/154 (37.0%), only first-line antihypertensive 111/154 (72.0%), and only non-first-line antihypertensives 21/154 (13.6%), and combination of first-line and non-first-line antihypertensives 22/154 (14.2%). Antihypertension medication use varied based on age (p < 0.001), sex (p = 0.008), race (p = 0.001), body mass index (BMI) kg/m

conclusionsAmong MyHEART study participants, all of which had uncontrolled hypertension, 50.5% were not on an antihypertensive at enrollment. This finding supports the call to improve management of blood pressure earlier in life to potentially contribute to the reduction of long-term cardiovascular disease. Of the participants who were prescribed blood pressure medication, providers prescribed guideline-based antihypertensive therapy the majority of the time, however, this study indicates there may be an opportunity to increase the use of first-line, guideline-based antihypertensives, regardless of age, sex, or type of hypertension to lower long-term cardiovascular risk.

trial registrationhttps://www. CLINICALTRIALS: gov Identifier: NCT03158051, registered 5-15-2017. IRB approval obtained: IRB # 2017 - 0372.

Indexed as

Antihypertensive AgentsBlood PressureGuideline AdherenceHypertensionPractice Guidelines as TopicPractice Patterns, Physicians'AdultAge FactorsCross-Sectional StudiesDrug PrescriptionsDrug Therapy, CombinationFemaleHumansMaleMiddle AgedRetrospective StudiesAntihypertensive AgentsAntihypertensive medicationUncontrolled hypertensionYoung adult

Identifiers

PMID39538139
PMCPMC11559136

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.