Evidence map›Paper›PMID 39538100›Full record

SynthesisAnnals of surgical oncology2025

Society of Surgical Oncology Breast Disease Site Working Group Statement on Bilateral Risk-Reducing Mastectomy: Indications, Outcomes, and Risks.

Puneet Singh, Doreen M Agnese, Miral Amin, Andrea V Barrio, Astrid Botty van den Bruele, Erin E Burke, David N Danforth, Frederick M Dirbas, Firas Eladoumikdachi, Oluwadamilola M Fayanju and 16 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Puneet SinghDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. puneetsinghmd@gmail.com.
Doreen M AgneseThe Ohio State University, Columbus, OH, USA.
Miral AminPrivate Practice, Southlake, TX, USA.
Andrea V BarrioMemorial Sloan Kettering Cancer Center, New York City, NY, USA.
Astrid Botty van den BrueleDuke University Medical Center, Durham, NC, USA.
Erin E BurkeThe Ohio State University, Columbus, OH, USA.
David N Danforth, Chevy Chase, MD, USA.
Frederick M DirbasStanford University School of Medicine, Stanford, CA, USA.
Firas EladoumikdachiRutgers Cancer Institute, Hamilton, NJ, USA.
Oluwadamilola M FayanjuPenn Medicine, Philadelphia, PA, USA.
Olga KantorBrigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Shicha KumarRutgers Cancer Institute, New Brunswick, NJ, USA.
Marie Catherine LeeMoffitt Cancer Center, Tampa, FL, USA.
Cindy MatsenUniversity of Utah, Salt Lake City, UT, USA.
Toan T NguyenLakeland Regional Health, Lakeland, FL, USA.
Tolga OzmenMassachusetts General Hospital, Boston, MA, USA.
Ko Un ParkBrigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Jennifer K PlichtaDuke University Medical Center, Durham, NC, USA.
Chantal ReynaLoyola University, Chicago, IL, USA.
Shayna L ShowalterUniversity of Virginia, Charlottesville, VA, USA.
Toncred StybloEmory University, Atlanta, GA, USA.
Nicholas TranakasBroward Surgical Associates, Fort Lauderdale, FL, USA.
Anna WeissUniversity of Rochester Medical Center, Rochester, NY, USA.
Ashley WoodfinUniversity of Wisconsin-Madison, Madison, WI, USA.
Christine LarongaMoffitt Cancer Center, Tampa, FL, USA.
Judy C BougheyMayo Clinic, Rochester, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bilateral risk-reducing mastectomy (BRRM) is the surgical removal of both breasts to reduce the risk of cancer. In this Society of Surgical Oncology position statement, we review the literature addressing the indications, outcomes, and risks of BRRM to update the society's 2017 statement. We held a virtual meeting to outline key topics and conducted a literature search using PubMed to identify relevant articles. After literature review, recommendations were made according to group consensus. Individuals with a high lifetime risk of breast cancer due to pathogenic variants in high penetrance breast cancer-predisposition genes, early chest or breast radiation exposure, or a compelling family history should be counseled on the option of BRRM. However, BRRM is not recommended for most patients with high-risk lesions and may be contraindicated in patients who have other competing cancers and/or a high risk of surgical complications. BRRM effectively reduces the risk of breast cancer development, although the survival benefit is unclear. For patients with low-to-moderate breast cancer risk, alternative management strategies should be encouraged, including lifestyle modifications, high-risk screening, and risk-reducing medications. Discussions of BRRM should cover: (1) breast-cancer risk estimates; (2) the procedure's degree of risk reduction and impact on survival; (3) surgical techniques, potential surgical complications and long-term sequelae; and (4) alternatives to surgery. Surgeons should encourage shared and informed decision making with patients who have an elevated lifetime risk of developing breast cancer.

Indexed as

Breast NeoplasmsMastectomySocieties, MedicalSurgical OncologyFemaleHumansPrognosisProphylactic MastectomyRisk FactorsRisk Reduction BehaviorBilateral risk-reducing mastectomyBreast cancerBreast cancer-predisposition geneHigh-risk lesionHigh-risk screeningNipple-sparing mastectomyRisk-reducing medicationRisk reduction

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.