Evidence map›Paper›PMID 39538090›Full record

ArticleInflammation2025

Fibroblast growth factor 10 alleviates LPS-induced acute lung injury by promoting recruited macrophage M2 polarization.

Nana Feng, Yufan Li, Fengxia Guo, Juan Song, Lu Wang, Miao Li, Kaijing Gao, Xiaocen Wang, Dejie Chu, Yuanlin Song and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nana Feng *Department of Respiratory and Critical Medicine, Shanghai Eighth People's Hospital, Shanghai, 200235, China.
Yufan Li *Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Fengxia Guo *Department of Respiratory and Critical Medicine, Shanghai Eighth People's Hospital, Shanghai, 200235, China.
Juan SongDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Lu WangDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Miao LiDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Kaijing GaoDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xiaocen WangDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Dejie ChuDepartment of Respiratory and Critical Medicine, Shanghai Eighth People's Hospital, Shanghai, 200235, China. djchu@sina.com.
Yuanlin SongDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. song.yuanlin@zs-hospital.sh.cn.
Linlin WangDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. siyuxueer@163.com.

Funding

Clinical Medicine Foundation of Jiangsu University JLY20180016, JLY20180124National Natural Science Foundation of China 8200087, 81900007, 81270132Scientific Research Project of Shanghai Municipal Health Committee Project 20204Y0082Shanghai Xuhui District Science Committee Project SHXH201838
6 · The paper itself

Abstract

Acute lung injury (ALI) is characterized by damage to the alveoli and an overabundance of inflammation. Representing a serious inflammatory condition, ALI lacks a precise treatment approach. Despite the recognized benefit impacts of Fibroblast growth factor-10 (FGF10) on ALI, the underlying mechanisms remain unelucidated. To study the role of FGF10 in ALI, C57BL/6 J mice were intratracheally injected with 5 mg/kg Lipopolysaccharide (LPS) with FGF10 (5 mg/kg) or an equal volume of PBS. Inflammatory factors were quantified in bronchoalveolar lavage fluid (BALF) and plasma using ELISA. RNA sequencing of F4/80

Indexed as

Acute Lung InjuryFibroblast Growth Factor 10Macrophage ActivationMacrophagesAnimalsBronchoalveolar Lavage FluidCell PolarityLipopolysaccharidesMaleMiceMice, Inbred C57BLSTAT3 Transcription FactorFibroblast Growth Factor 10LipopolysaccharidesSTAT3 Transcription FactorAcute lung injuryARG1Fibroblast Growth Factor 10Macrophage

Identifiers

PMID39538090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.