Evidence map›Paper›PMID 39537991›Full record

ArticleVirchows Archiv : an international journal of pathology2025

Sclerosing mucoepidermoid carcinoma of salivary glands.

Bacem Khalele Othman, Martina Bradová, Roderick H W Simpson, Jan Laco, Abbas Agaimy, Miguel Rito, Stephan Ihrler, Petr Steiner, Petr Grossmann, Veronika Hájková and 7 more

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Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bacem Khalele OthmanDepartment of Pathology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Martina BradováDepartment of Pathology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Roderick H W SimpsonDepartment of Pathology, University of Calgary, Calgary, Alberta, Canada.
Jan LacoThe Fingerland Department of Pathology, Faculty of Medicine, Charles University, Hradec Králové and University Hospital Hradec Králové, Hradec Králové, Czech Republic.
Abbas AgaimyInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen, Germany.
Miguel RitoDepartment of Pathology, Faculdade de Medicina, Instituto Português de Oncologia de Lisboa Francisco Gentil & Institute of Pathology, Universidade de Lisboa, Lisbon, Portugal.
Stephan IhrlerDERMPATH, Munich, Germany.
Petr SteinerMolecular and Genetic Laboratory, Bioptic Laboratory, Ltd, Pilsen, Czech Republic.
Petr GrossmannMolecular and Genetic Laboratory, Bioptic Laboratory, Ltd, Pilsen, Czech Republic.
Veronika HájkováMolecular and Genetic Laboratory, Bioptic Laboratory, Ltd, Pilsen, Czech Republic.
Gisele de RezendeDepartment of Anatomic Histopathology and Cytogenetics, Department of Laboratory Medicine, Niguarda Cancer Center, Milan, Italy.
Montse GomaDepartment of Pathology, Hospital Universitari de Bellvitge, Barcelona, Spain.
Senada KoljenovicDepartment of Pathology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.
Isabel FonsecaDepartment of Pathology, Faculdade de Medicina, Instituto Português de Oncologia de Lisboa Francisco Gentil & Institute of Pathology, Universidade de Lisboa, Lisbon, Portugal.
Michal MichalDepartment of Pathology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Ilmo Leivo *Institute of Biomedicine, Pathology, University of Turku and Department of Pathology, Turku University Hospital, Turku, Finland.
Alena Skalova *Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic. skalova@biopticka.cz.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sclerosing mucoepidermoid carcinoma (SMEC) of the salivary glands is a rare variant of low-grade mucoepidermoid carcinoma with scanty cellular atypia characterized by marked fibrosis/sclerosis and a rich inflammatory infiltrate. Herein, we report 25 unpublished cases of SMEC, two of them with prominent eosinophilia (2/25; 8%) and three with abundant IgG4-positive plasma cells (3/25; 12%). In our series of salivary SMEC, molecular analysis using fluorescence in situ hybridization (FISH) and/or next-generation sequencing (NGS) provided evidence of MAML2 gene rearrangement in 18 cases of the 21 analyzable cases tested (86%), while this gene locus was intact in 3 cases (14%). This study focuses on the diagnostic criteria of salivary SMEC given its challenge of abundant collagenous stroma, minimal residual neoplastic areas, and inconspicuous mucous cells. Follow-up data of our cases indicate that salivary SMECs have favorable outcomes. Molecular analysis for MAML2 gene rearrangement suggests that SMECs of salivary glands represent a rare variant of conventional low-grade MECs of salivary glands. In contrast, SMECs of the thyroid gland are genetically distinct from salivary-type thyroid MECs.

Indexed as

Carcinoma, MucoepidermoidSalivary Gland NeoplasmsAdultAgedBiomarkers, TumorDNA-Binding ProteinsFemaleGene RearrangementHigh-Throughput Nucleotide SequencingHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedSclerosisTrans-ActivatorsTranscription FactorsBiomarkers, TumorDNA-Binding ProteinsMAML2 protein, humanTrans-ActivatorsTranscription FactorsIgG4Keloid-like stromal fibrosisMAML2 rearrangementSalivary glandSclerosing mucoepidermoid carcinomaSclerosisSMECTissue eosinophilia

Identifiers

PMID39537991
PMCPMC12289853

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.